Registration Dossier
Registration Dossier
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EC number: 242-640-5 | CAS number: 18871-14-2
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 14 2014
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The information is derived from a reliable non-GLP in-house study according to OECD TG 117 (HPLC).
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- GLP compliance:
- no
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Key result
- Type:
- log Pow
- Partition coefficient:
- 3.2 - 3.7
- Temp.:
- 25 °C
- Remarks on result:
- other: pH is not considered to be critical based on the absence of acidic and basis structural features in its molecular structure. Therefore the pH of the solution is expected to be around 7.
- Details on results:
- Like the standard materials, the test material is retained in proportion to its hydrocarbon-water partition coefficient. Water-soluble chemicals elute first, followed by oil-soluble chemicals. The relationship between the retention time on a C8 column and hydrophobicity can be established. The partition coefficient is calculated from the capacity factor k, given by the expression k = (tR-t0 ) / t0 where, tr is the retention time of the test substance, and t0 is the dead-time, i.e. the average time a solvent molecule needs to pass the column.
- Conclusions:
- The partition coefficient of Jasmal has been determined as log P =3.2-3.7 at 25°C under a study equivalent to OECD Guideline 117 (HPLC method) in a reliable non-GLP study.
- Executive summary:
The partition coefficient of Jasmal has been determined as log P = 3.2 -3.7 at 25°C under a studyequivalent to OECD Guideline 117 (HPLC Method). The value of 3.2 has been selected for the risk assessment because this value is related to the trans-isomer which is the main constituent and is expected to have the lower log Kow value.
Reference
Description of key information
The partition coefficient of Jasmal has been determined as log P = 3.2 -3.7 at 25°C in a study equivalent to OECD Guideline 117 (HPLC Method). The value of 3.2 has been selected for the risk assessment because this value is related to the trans-isomer which is the main constituent and is expected to have the lower log Kow value.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 3.2
- at the temperature of:
- 25 °C
Additional information
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