Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from Australian Safety and Compensation Council and US Environmental Protection Agency

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
NATIONAL INDUSTRIAL CHEMICALS NOTIFICATION AND ASSESSMENT SCHEME (NICNAS)
Author:
Australian Safety and Compensation Council
Year:
2006
Bibliographic source:
NICNAS, FULL PUBLIC REPORT: STD/1159, 24 April 2006
Reference Type:
secondary source
Title:
Robust summary alkyl sulfide catetgory CAS # 68515-88-8 health elements: Acute toxicity
Author:
US Environmental Protection Agency
Year:
2000
Bibliographic source:
US Environmental Protection Agency, AR201-12549bZ, 2000

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: FHSA Regulations 16 CFR 1500.40
Principles of method if other than guideline:
Acute dermal toxicity study of Pentene, 2, 4, 4-trimethyl-, sulfurized in rabbits
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Pentene, 2,4,4-trimethyl-, sulfurized
EC Number:
271-114-8
EC Name:
Pentene, 2,4,4-trimethyl-, sulfurized
Cas Number:
68515-88-8
Molecular formula:
C24H50S8
IUPAC Name:
1-(2,4,4-trimethyl-1-{[(2,4,4-trimethylpentan-2-yl)disulfanyl]disulfanyl}pentan-2-yl)-4-(2,4,4-trimethylpentan-2-yl)tetrasulfane
Details on test material:
SMILES:CC(C)(C)CC(C)(C)SSSSCC(C)(CC(C)(C)C)SSSSC(C)(C)CC(C)(C)C
Specific details on test material used for the study:
- Name of test material: Pentene, 2, 4, 4-trimethyl-, sulfurized
- EC name: Pentene, 2,4,4-trimethyl-, sulfurized
- Molecular formula: C24H50S8
- Molecular weight: 594.141 g/mole (As in Chem exper)
- Substance type: Organic
- Physical state: Liquid
- Purity: 97 %

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Type of coverage:
occlusive
Vehicle:
water
Remarks:
Mineral oil-based material dosed undiluted
Details on dermal exposure:
The sample was applied to unabraded shaved skin under impervious occlusion for 24 hours at a limit dose of 2.0 mg/kg At the end of the 24-hour exposure period, the wrapping was removed any unabsorbed test material remaining on the skin was removed by gentle sponging using a paper towel moistened with mineral oil
Duration of exposure:
24 hours
Doses:
2000 mg/kg
No. of animals per sex per dose:
5 male and 5 female
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Frequently on the day of treatment. Thereafter, all surviving rabbits were examined for outward signs of toxicity one per day, for the entire 14-day observation period. Individual weights were recorded on the day of dosage, weekly thereafter and prior to sacrifice.
- Necropsy of survivors performed: Yes
- Other examinations performed: Clinical signs, body weight and gross pathology were examined.
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No 50 % mortality observed
Mortality:
One rabbit died on day 14 of the study.
Clinical signs:
other: Bloated appearance and Signs of dehydrationIn was observed in dead male rats.
Gross pathology:
No formed fecal material in the intestinal tract were noted for the one mortality and no gross pathological changes were observed in treated female rats.
Other findings:
In the male rat, mild skin erythema and mild to moderate edema were observed after unwrapping at 24 hours. Slight to mild skin irritation noted at 7 day was completely resolved by day 14.

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 was considered to be > 2000 mg/kg for when male and female New Zealand white rabbit were exposed to Pentene, 2, 4, 4-trimethyl-, sulfurized.
Executive summary:

In acute dermal toxicity study, male and femaleNew Zealand white rabbit wereexposed toPentene, 2, 4, 4-trimethyl-, sulfurized in the concentration of 2000 mg/kg.Results shows that one male rabbit is died and all other survive till the end of study. Bloated appearance and Signs of dehydrationIn was observed in dead male rats. One male and female rat decrease in body weight were observed on day 7. In the male rat, mild skin erythema and mild to moderate edema were observed after unwrapping at 24 hours. Slight to mild skin irritation noted at 7 day was completely resolved by day 14. No formed fecal material in the intestinal tract was noted for the one mortality and no gross pathological changes were observed in treated female rats. Therefore, LD50 was considered to be > 2000 mg/kg when male and female New Zealand white rabbit were exposed to Pentene, 2, 4, 4-trimethyl-, sulfurized for 24 hour dermally.