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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Data is from secondary safety data sheet .

Data source

Reference
Reference Type:
secondary source
Title:
Safety data sheet
Author:
Safety data sheet-TAKASAGO
Year:
2015
Bibliographic source:
Safety data sheet-TAKASAGO-Revision No: 1, Revision Date: 27 May 2015

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
The skin sensitization study of 2-Buten-1-ol, 2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)- was conducted in guinea pigs to determine its sensitization potential.
GLP compliance:
not specified
Type of study:
guinea pig maximisation test
Justification for non-LLNA method:
not specified

Test material

Constituent 1
Reference substance name:
2-Buten-1-ol, 2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-
IUPAC Name:
2-Buten-1-ol, 2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-
Constituent 2
Chemical structure
Reference substance name:
2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol
EC Number:
248-907-2
EC Name:
2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol
Cas Number:
28219-60-5
Molecular formula:
C13H22O
IUPAC Name:
2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol
Details on test material:
- Name of test material (as cited in study report): 2-Methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol
- Molecular formula : C13H22O
- Molecular weight : 194.316 g/mol
- Substance type: organic
- Physical state: liquid

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No Data Available

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
other:
Vehicle:
other: Ethanol
Concentration / amount:
30% in ethanol
Challenge
Concentration / amount:
30% in ethanol
No. of animals per dose:
No Data Available
Details on study design:
No Data Available
Challenge controls:
No Data Available
Positive control substance(s):
not specified

Results and discussion

Positive control results:
No Data Available

In vivo (non-LLNA)

Results
Reading:
1st reading
Group:
test chemical
Dose level:
30% in ethanol
No. with + reactions:
0
Clinical observations:
not sensitising
Remarks on result:
other: Reading: 1st reading. Group: test group. Dose level: 30% in ethanol. No with. + reactions: 0.0. Clinical observations: not sensitising.

Any other information on results incl. tables

No Data Available

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Conclusions:
The test material 2-Buten-1-ol, 2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)- (CAS No: - 28219-60-5) was observed to be not sensitizing to guinea pigs.
Executive summary:

The skin sensitization study of 2-Buten-1-ol, 2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)- (CAS No: -28219-60-5) was performed in guinea pigs to observed its sensitizing efficacy by Guinea pig maximization test.

 

The test sample was applied at concentration of 30% in ethanol.

 

Since no skin reactions were observed, the test chemical 2-Buten-1-ol, 2-methyl-4-(2, 2, 3-trimethyl-3-cyclopenten-1-yl) - (CAS No: -28219-60-5) was found to be non sensitizing in guinea pigs.