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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: data from safety data sheets

Data source

Reference
Reference Type:
secondary source
Title:
SANTALIFF BHT
Author:
INTERNATIONAL FLAVORS & FRAGRANCES
Year:
2011
Bibliographic source:
Material Safety Data Sheet, INTERNATIONAL FLAVORS & FRAGRANCES, 02/14/2011

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess the ocular irritation potential of the test chemical
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol
EC Number:
248-907-2
EC Name:
2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol
Cas Number:
28219-60-5
Molecular formula:
C13H22O
IUPAC Name:
2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol
Constituent 2
Reference substance name:
2-Methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)but-2-en-1-ol
IUPAC Name:
2-Methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)but-2-en-1-ol
Test material form:
other: liquid
Details on test material:
Name of test material (as cited in study report): 2-Methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)but-2-en-1-ol
Molecular formula:C13H22O
Molecular weight :194.316 g/mol
SMILES: OCC(=CCC(C(C(=C1)C)(C)C)C1)C
Substance type: Organic
Physical state: Liquid

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
no data

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
undiluted test sample
Duration of treatment / exposure:
no data
Observation period (in vivo):
no data
Number of animals or in vitro replicates:
no data

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: no data
Remarks on result:
other: moderate irritation observed

Applicant's summary and conclusion

Interpretation of results:
moderately irritating
Conclusions:
An eye irritation study in rabbits was performed in rabbits. 2-Methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)but-2-en-1-ol was considered to be moderately irritating to rabbit eyes.
Executive summary:

An eye irritation study in rabbits was performed in rabbits. Undiluted test sample was instilled into rabbit eyes. Effects were observed.2-Methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)but-2-en-1-ol was considered to be moderately irritating to rabbit eyes.