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Short term toxicity to aquatic invertebrates:

Various predicted studies of the test compound 2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol to aquatic invertebrates were reviewed from reliable sources.

48 hrs aquatic toxicity studies (SSS QSAR prediction model, 2016) were conducted to assess toxic effects of the 2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol (CAS no 28219-60-5) and the results were predicted. The study was based on the effects of the test compound on the Daphnia magna in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the 2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol (CAS no 28219-60-5) was estimated to be 0.035537671 mg/L on the basis of intoxication.

48 hrs aquatic toxicity studies (EPI suite, ECOSAR version 1.1, 2016) were conducted to assess toxic effects of the 2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol (CAS no 28219-60-5) and the results were predicted. The study was based on the effects of the test compound on the Daphnia magna in a static fresh water system. The predicted data suggests the lethal concentration (LC50) for the 2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol was estimated to be 0.486 mg/L.

On the basis of results for toxicity to aquatic invertebrates, it can be considered that the substance is likely to be toxic to aquatic biota and can be classified in Acute category 1 as per the criteria of CLP regulation Toxicity to aquatic algae and cyanobacteria

Toxicity to aquatic algae and cyanobacteria

Various predicted data for the test chemical2-Buten-1-ol, 2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-(CAS No. 28219-60-5)were reviewed to summarize the following information:

 

72 hrs aquatic toxicity study was predicted (SSS QSAR Prediction model, 2016) to assess toxic effects of the test compound 2-Buten-1-ol, 2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)- (CAS no.28219 -60 -5) and the result were predicted. The study was based on the effects of the test compound on Desmodesmus subspicatus in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the test compound 2-Buten-1-ol, 2-methyl-4-(2,2,3 - trimethyl-3 -cyclopenten-1 -yl)- (CAS no. 28219 -60 -5) was estimated to be 0.702 mg/l on the basis of effects on population.

 

Based on the QSAR prediction done using the EPI Suite ECOSAR version 1.10 (EPI Suite, 2016), the 96 hours EC50 was estimated to be 0.995 mg/l on green algae for substance 2-Buten-1-ol, 2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)- with growth inhibition effects.

 

Based on the overall reported results for target substance, it can be concluded that the substance2-Buten-1-ol,2-methyl-4-(2,2,3-trimethyl-3

-cyclopenten-1-yl)-can be considered as toxic to aquatic organisms and thus can be classified as aquatic acute category 1 as per the CLP criteria.