Registration Dossier
Registration Dossier
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EC number: 406-176-9 | CAS number: 79072-96-1 NC-4
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Duration:
- 5 d
- % Recovery:
- > 90
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- other: At pH 7 less than 10% of the substance hydrolysed within 5 days
- % Recovery:
- > 90
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- other: At pH 9 less than 10% of the substance hydrolysed within 5 days
- % Recovery:
- 10
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- other: At pH 4 90% of the substance hydrolysed to 4-ethylbenzaldehyde
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Substance was found to be stable at pH 7.0 and 9.0. At pH 4.0 the substance was found to hydrolyse.
- Endpoint:
- hydrolysis
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- the study does not need to be conducted because the substance is highly insoluble in water
Referenceopen allclose all
Description of key information
Available data on the test substance (12 year data obtained from ECHA inquiry process) showed that at pH 7 and 9 at 50°C less than 10% of the substance hydrolysed within 5 days. At pH 4 under the same conditions 90% of the substance hydrolysed.
The substance was found to be stable at pH 7.0 and 9.0. At pH 4.0 the substance was found to hydrolyse. Under environmentally relevant conditions the substance is therefore assumed to be stable.
Due to the substance being highly insoluble in water, a further OECD 111 study is not considered to be necessary.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
