Registration Dossier
Registration Dossier
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EC number: 942-637-5 | CAS number: 1844064-90-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30/03/2014-21/04/2014
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1-[4-bromo-3-(chloromethyl)phenyl]ethan-1-one
- EC Number:
- 942-637-5
- Cas Number:
- 1844064-90-9
- Molecular formula:
- C9H8BrClO
- IUPAC Name:
- 1-[4-bromo-3-(chloromethyl)phenyl]ethan-1-one
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Vehicle:
- other: aqua ad injectionem
- Amount / concentration applied:
- 0.5 g per test site
- Duration of treatment / exposure:
- 4 hours
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: 1-3
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Irritation parameter:
- edema score
- Basis:
- animal: 1-3
- Time point:
- 24/48/72 h
- Score:
- 0.55
Any other information on results incl. tables
The single dermal application of the test item showed irritant but no corrosive effects which were fully reversible within 8 days in animal no.3 but were not fully reversible until the end of the extended observation period of 14 days in animals no.1 and 2.
Neither mortalities nor significant clinical signs of toxicity were observed.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
The test item has obligatory labelling requirement for skin irritation.
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