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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
data is from NTRL reports

Data source

Reference
Reference Type:
review article or handbook
Title:
FINAL REPORT, PRIMARY DERMAL IRRITATION AND OCULAR IRRITATION (RABBIT), AND ACUTE ORAL TOXICITY (RAT) OF NONYLPHENOL ETHOXYLATES (NPES), WITH COVER LETTER DATED 10/14/96
Author:
LONZA INC
Year:
1996
Bibliographic source:
OTS0558916, submitted by LONZA INC.; last updated 1996

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Primary Ocular irritation test was conducted in rabbits to evaluate the irritation potential of 4-Nonylphenol, branched, ethoxylated
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): 4-Nonylphenol, branched, ethoxylated
- Molecular formula : C17H28O2
- Molecular weight : 264.409 g/mol
- Substance type:Organic
- Physical state: Liquid
Specific details on test material used for the study:
- Name of test material (as cited in study report): 4-Nonylphenol, branched, ethoxylated
- Molecular formula: C17H28O2
- Molecular weight: 264.409 g/mol
- Substance type: Organic
SMILES: CCCC(C)CC(C)Cc1ccc(OCCOCCOCCOCCOCCO)cc1
- Physical state: Liquid

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
TEST ANIMALS
Sex: Male and Female
- Source: Summit View Farm, Belvidere, New Jersey
- Age at study initiation: No data available
- Weight at study initiation: 1.8 - 2.4 kg
- Fasting period before study: No data available
- Housing: No data available
- Diet (e.g. ad libitum): ad libitum with Wayne animal feeds used exclusively
- Water (e.g. ad libitum): ad libitum
- Acclimation period: No data available

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
0.1 ml
Duration of treatment / exposure:
single application
Observation period (in vivo):
24 hours to 7 days
Duration of post- treatment incubation (in vitro):
no data available
Number of animals or in vitro replicates:
6
Details on study design:
Details on study design

REMOVAL OF TEST SUBSTANCE
- Washing (if done): No washing
SCORING SYSTEM: Draize method

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
7 d
Score:
3.2
Reversibility:
not specified
Remarks on result:
probability of moderate irritation
Irritant / corrosive response data:
Under the test conditions, 4-Nonylphenol, branched, ethoxylated was moderate ocular irritant.

Any other information on results incl. tables

 

Table 1:

Draize Scores

Group

Draize Scores

Days

1

2

3

4

7

No wash

21.8

20.3

11.7

5.7

3.2

 

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritating to eyes) based on GHS criteria
Conclusions:
The Draize score after 7 days was 3.2.
Under the test conditions, 4-Nonylphenol, branched, ethoxylated was moderate ocular irritant.
Hence, 4-Nonylphenol, branched, ethoxylated can be considered to be moderately irritating to rabbit eyes.
Executive summary:

Primary Ocular irritation test was conducted in rabbits to evaluate the irritation potential of 4-Nonylphenol, branched, ethoxylated.

6 male and female rabbits weighing1.8 - 2.4 kg were used for the study. 0.1 ml single administration of4-Nonylphenol, branched, ethoxylated (Carsonon N-10, 5% Active in Distilled Water) was instilled into the rabbit eyes. The treated eyes were not washed for 24 hours and up to seven day observation. The effects observed were scored according to Draize method.

The Draize score after 7 days was 3.2.

Under the test conditions, 4-Nonylphenol, branched, ethoxylated was moderate ocular irritant.

Hence, 4-Nonylphenol, branched, ethoxylated can be considered to be moderately irritating to rabbit eyes.