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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
05/02/1979 to 27/03/1979
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from secondary source

Data source

Reference
Reference Type:
secondary source
Title:
FINAL REPORT, PRIMARY DERMAL IRRITATION AND OCULAR IRRITATION (RABBIT), AND ACUTE ORAL TOXICITY (RAT) OF NONYLPHENOL ETHOXYLATES (NPES), WITH COVER LETTER DATED 10/14/96
Author:
LONZAINC
Year:
1996
Bibliographic source:
OTS0558916, CONSUMER PROD TESTING CO INC, page no 1-15

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as below
Principles of method if other than guideline:
Acute oral toxicity study of Carsonon N-10 in rats
GLP compliance:
not specified
Test type:
other: No data
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): 4-Nonylphenol, branched, ethoxylated
- Molecular formula : C17H28O2
- Molecular weight : 264.409 g/mol
- Substance type:Organic
- Physical state: Liquid
Specific details on test material used for the study:
- Name of test material (as cited in study report): Poly(oxy-1,2-ethanediyl), .alpha.-(4-nonylphenyl)-.omega.-hydroxy-, branched
- Molecular formula (if other than submission substance): C23H40O5
- Molecular weight (if other than submission substance): 396.63 g/mol
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rat
Strain:
other: Albino
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Source:Summit View Farm, Belvidere, New Jersey
- Age at study initiation:No data available
- Weight at study initiation:194-244 g
- Fasting period before study: No data available
- Housing: No data available
- Diet (e.g. ad libitum): with Wayne animal feeds used exclusively, ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: No data available

ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%):No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
DOSAGE PREPARATION (if unusual): 100 %
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
5 male, 5 female
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
< 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Mortality observed
Mortality:
When treated wtih 5000 mg/kg bw, all the treated male and female rats were dead
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Any other information on results incl. tables

Dose Level

(g/kg)

Sex

Dead/ dosed

%

5.0

5M/ 5F

5/5 : 5/5

100

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
LD50 was considered to be < 5000 mg/kg bw when male and female rats were treated with Carsonon N-10 (Poly(oxy-1,2-ethanediyl), .alpha.-(4-nonylphenyl)-.omega.-hydroxy-, branched ) orally.
Executive summary:

In a acute oral toxicity study, male and female rats by using Carsonon N-10 (Poly(oxy-1,2-ethanediyl), alpha-(4-nonylphenyl)-omega-hydroxy-, branched) in the concentration of 5000 mg/kg bw orally. All the treated male and female rats were dead at 5000 mg/lg bw. Therefore, LD50 was considered to be < 5000 mg/kg bw when male and female rats were treated with Carsonon N-10 (Poly(oxy-1,2-ethanediyl), alpha-(4-nonylphenyl)-omega-hydroxy-, branched) orally.