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Ecotoxicological information

Toxicity to microorganisms

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Reference
Endpoint:
activated sludge respiration inhibition testing
Type of information:
experimental study
Adequacy of study:
key study
Study period:
no data
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
The study was performed according to a valid guideline without any deviations and was conducted under GLP conditions. Furthermore, the data were submitted by another legal entity, under Directive 67/548/EEC, at least 12 years previously. The registrant has been granted permission to use the information, which has been extracted from the ECHA databases, for REACH registration purposes. No full information related to the experimental result are available but these deficiencies do not affect the quality of the relevant results.
Qualifier:
according to
Guideline:
EU Method C.11 (Biodegradation: Activated Sludge Respiration Inhibition Test)
Version / remarks:
87/302/EEC
Deviations:
not specified
GLP compliance:
yes
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material (migrated information):
no data
Analytical monitoring:
not specified
Details on sampling:
no data
Vehicle:
not specified
Details on test solutions:
no data
Test organisms (species):
other: no data
Details on inoculum:
no data
Test type:
other: aerobic
Water media type:
not specified
Total exposure duration:
3 h
Remarks on exposure duration:
no data
Post exposure observation period:
no data
Hardness:
no data
Test temperature:
no data
pH:
no data
Dissolved oxygen:
no data
Salinity:
no data
Conductivity:
no data
Nominal and measured concentrations:
no data
Details on test conditions:
no data
Reference substance (positive control):
not specified
Duration:
3 h
Dose descriptor:
IC50
Effect conc.:
> 1 000 mg/L
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
not specified
Duration:
3 h
Dose descriptor:
NOEC
Effect conc.:
1 000 mg/L
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
not specified
Details on results:
no data
Results with reference substance (positive control):
no data
Reported statistics and error estimates:
no data

no data

Validity criteria fulfilled:
not specified
Conclusions:
Under the test conditions, the effect of the test material on the respiration of activated sewage sludge microorganisms gave a 3 h EC50 > 1000 mg/l.
The No Observed Effect Concentration (NOEC) was equal to 1000 mg/l.
Executive summary:

An experimental study was performed in order to investigate the toxicity to microorganisms, under GLP conditions and according to EU Method C.11.

Under the test conditions, the effect of the test material on the respiration of activated sewage sludge microorganisms gave a 3 h EC50 > 1000 mg/l.

The NOEC was equal to 1000 mg/l.

Description of key information

The effect of the test material on the respiration of activated sewage sludge microorganisms gave a 3 h EC50 > 1000 mg/l. 
The NOEC was equal to 1000 mg/l.

Key value for chemical safety assessment

EC50 for microorganisms:
1 000 mg/L
EC10 or NOEC for microorganisms:
1 000 mg/L

Additional information

no data