Registration Dossier

Physical & Chemical properties

Dissociation constant

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
dissociation constant
Data waiving:
study technically not feasible
Justification for data waiving:
the study does not need to be conducted because the substance is insoluble
Reason / purpose:
data waiving: supporting information
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
Deviations:
not specified
Qualifier:
equivalent or similar to
Guideline:
EPA OPPTS 830.7370 (Dissociation constants in water)
Deviations:
not specified
GLP compliance:
not specified
Specific details on test material used for the study:
no data
Conclusions:
Testing proposal.

Description of key information

According to ECHA Guideline (Chapter R.7a: Endpoint specific guidance. Version 5.0. 2016) The result of the property Dissociation constant refers only to acid dissociation (pKa).

As it is possible to see at section 4.8 Water solubility, the substance is only slightly soluble (0.1-100 mg/L) @ 20°C.

Because of the previous reasons, no testing is proposed in this registration dossier.

Key value for chemical safety assessment

Additional information