Registration Dossier

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

LC50 (96 h): 35.4 mg/L based on mortality of D. rerio (OECD 203).

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
35.4 mg/L

Additional information

One experimental study was conducted according to OECD 203 and GLP under static conditions. Prior to the definitive test the threshold approach was followed by conducting a limit test with a concentration of 100 mg/L. Since all fish died after 2 h of exposure an additional range-finding test followed by the definitive test with concentrations of 6.25, 12.5, 25.0, 50.0, 100 mg/L were conducted. The test concentrations were analysed by HPLC-DAD at the beginning and the end of exposure. Since they remained within 80-120% of nominal the effect concentrations were based on the nominal values. After 96 h 100% mortality was observed at 50 and 100 mg/L whereas 0% mortality was recorded in the remaining concentrations. The LC50 (96 h) was calculated at 35.4 mg/L (nominal).