Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2004-07-02 to 2004-11-25
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2005
Report Date:
2005

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Version / remarks:
27 July1995.
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Specific details on test material used for the study:
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: approximately 4°C, in the dark

Study design

Analytical method:
gas chromatography

Results and discussion

Partition coefficientopen allclose all
Key result
Type:
Pow
Partition coefficient:
0.53
Temp.:
22.8 °C
pH:
6.3
Key result
Type:
log Pow
Partition coefficient:
-0.276
Temp.:
22.8 °C
pH:
6.3

Any other information on results incl. tables

Temperature:  22.8 ± 0.5°C

The partition coefficient determined for each sample is shown in the following table:

 Sample Number

 n-Octanol/Water Volume Ratio

 Partition Coefficient

 Log10 Pow

 Mean Partition Coefficient

 1

3:2

 0.408

 -0.389

 see below

 2

 3:2

 0.616

 -0.211

 0.512

3

 3:1

 0.493

 -0.307

 see below

4

 3:1

 0.590

  -0.229

 0.542

 5

 6:1

 0.592

  -0.227

 see below

 6

 6:1

 0.478

  -0.321

 0.535

Mean Pow  : 0.530

log10 Pow : -0.276  Standard deviation : 8.22 x 10-2

Validation

The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 0 to 1000 mg/l for the organic matrix and 0 to 2500 mg/l for the aqueous matrix. These were satisfactory with correlation coefficients of 0.999 being obtained for both.

Recovery of analysis of each sample procedure was assessed and proved adequate for the test.

Recovery data is shown in the following table:

Phase

Nominal concentration
(mg/L)

Recovery range (%)

Mean recovery (%)

Aqueous

1000

84.2 to 86.9

85.8

Organic

100

26.2 to 34.3

30.2

 

Organic sample concentrations have been corrected for recovery of analysis.

Applicant's summary and conclusion

Conclusions:
The partition coefficient of the test material has been determined to be 0.530 at 22.8 ± 0.5°C, logPow -0.276.