Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report date:
2016

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
GLP compliance:
no
Type of method:
flask method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
(2H)chloroform
EC Number:
212-742-4
EC Name:
(2H)chloroform
Cas Number:
865-49-6
Molecular formula:
CCl3D
IUPAC Name:
chloroform
Test material form:
liquid

Study design

Analytical method:
gas chromatography

Results and discussion

Partition coefficientopen allclose all
Key result
Type:
log Pow
Partition coefficient:
1.5
Temp.:
20 °C
Remarks on result:
other: calculated value (EPI suite)
Remarks:
due to high volatility of the substance, the calculated value (EPI suite) of log Pow in the study report is considered more reliable in terms of further assessment than the measured results.
Type:
log Pow
Partition coefficient:
> 1.6
Temp.:
23 °C
pH:
9
Remarks on result:
not determinable
Remarks:
due to high volatility of the substance, all measurements of D-Chloroform in the aqueous phase were below the detection limit of the analytical system.
Details on results:
Partition coefficients of the shake flask method at pH 9:
Experiment No.:
1A) Pow >38.0, log Pow >1.58
1B) Pow >39.9, log Pow >1.60
2A) Pow >20.5, log Pow >1.31
2B) Pow >20.4, log Pow >1.31
3A) Pow >11.2, log Pow >1.05
3B) Pow >10.6, log Pow >1.02

The partition coefficient showed a tendency within the measurement series. This tendency was caused because the concentration of the test item in water was in all tests below the detection limit. Following a conservative approach the highest value was given as result.This value is also in good accordance with the value obtained via EpiSuite (log Pow = 1.5).

Applicant's summary and conclusion