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Administrative data

Description of key information

Acute toxicity oral in rat was reported as LD50 890 mg/kg.

Acute toxicity dermal in rabbit was reported as LD50 2000 mg/kg.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1967
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: collection of data, but record lacks methodological details
Principles of method if other than guideline:
no data on guideline, Study period lies before the acceptance of guidelines
GLP compliance:
not specified
Remarks:
Data retrieval was performed in 2016 by using RTECS. Toxicity values without further details are given. The cited reference lacks information on GLP compliance and year of study.
Test type:
other: no data, but probable standard acute method
Specific details on test material used for the study:
no specific details given
Species:
rat
Route of administration:
oral: unspecified
Key result
Dose descriptor:
LD50
Effect level:
ca. 890 mg/kg bw
Based on:
not specified
Interpretation of results:
Category 4 based on GHS criteria
Executive summary:

Acute toxicity oral in rat was reported in RTECS as LD50 890 mg/kg,

Toxicity data reference: Industrial Hygiene Foundation of America, Chemical and Toxicilogical Series, Bulletin (Pittburgh, Pa) 1947 -69

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
890 mg/kg bw
Quality of whole database:
Study period lay before the acceptance of guidelines, but reliable authors

Acute toxicity: via dermal route

Link to relevant study records

Referenceopen allclose all

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1967
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: collection of data, but record lacks methodological details
Principles of method if other than guideline:
Probably standard dermal toxicity study
GLP compliance:
not specified
Remarks:
Data retrieval was performed in 2016 by using RTECS. Toxicity values without further details are given. The cited reference lacks information on GLP compliance and year of study.
Test type:
standard acute method
Specific details on test material used for the study:
no data given
Species:
rabbit
Key result
Dose descriptor:
LD50
Effect level:
ca. 2 000 mg/kg bw
Interpretation of results:
Category 4 based on GHS criteria
Executive summary:

Acute toxicity dermal in rabbit was reported as LD50 2000 mg/kg.

Toxicity data reference: Industrial Hygiene Foundation of America, Chemical and Toxicilogical Series, Bulletin (Pittburgh, Pa) 1947

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1990
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: collection of data, but record lacks methodological details
Specific details on test material used for the study:
98,9 - 100,2 %
Species:
rat
Strain:
Wistar
Sex:
male/female
Type of coverage:
not specified
Doses:
0, 200, 1000, 5000 mg/kg bw.
No. of animals per sex per dose:
5
Control animals:
yes
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Mortality:
no
Interpretation of results:
Category 5 based on GHS criteria
Executive summary:

Acute toxicity dermal in rat was reported in RTECS as LD50 >5000 mg/kg.

Data from Kiso to Rinsho Clinical Report (Yubunsha Co., Ltd., 1 -5. Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Additional information

Justification for classification or non-classification