Registration Dossier

Administrative data

Endpoint:
in vivo mammalian germ cell study: gene mutation
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No OECD or GLP defined.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1985

Materials and methods

Principles of method if other than guideline:
Method: other: no data
GLP compliance:
not specified
Type of assay:
Drosophila SLRL assay

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: no data

Test animals

Species:
Drosophila melanogaster
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: feed
Duration of treatment / exposure:
3 d
Frequency of treatment:
no data
Post exposure period:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
20, 30 ppm (feeding); 60 ppm (injection)
Basis:

No. of animals per sex per dose:
no data
Control animals:
not specified

Examinations

Tissues and cell types examined:
Sex-linked recessive lethal (SLRL) assay

Results and discussion

Test results
Sex:
not specified
Genotoxicity:
negative

Any other information on results incl. tables

RS-Freetext:
Negativ

      Lethals
 Compound  Feeding  Injection
 2,4 -Dichloronitrobenzene  -  -

Applicant's summary and conclusion

Executive summary:

In a feeding and injection Drosophila mutagenicity test the test substance was judged to be nonmutagenic.