Registration Dossier
Registration Dossier
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EC number: 211-279-5 | CAS number: 637-12-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer-reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Final Report of the Safety Assessment of Lithium Stearate, A1 u mi n u m Distearate, Aluminum Stearate, Aluminum Tristearate, Ammonium Stearate, Calcium Stearate, Magnesium Stearate, Potassium Stearate, Sodium Stearate, and Zinc Stearate.
- Author:
- American College of Toxicology
- Year:
- 1 982
- Bibliographic source:
- International Journal of Toxicology, 1982, vol. 1, no. 2, page-143-177
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: No data
- Principles of method if other than guideline:
- Acute oral toxicity study of Aluminum Stearate in rats
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- yes
Test material
- Reference substance name:
- Aluminium tristearate
- EC Number:
- 211-279-5
- EC Name:
- Aluminium tristearate
- Cas Number:
- 637-12-7
- Molecular formula:
- C18H36O2.1/3Al
- IUPAC Name:
- aluminium tristearate
- Test material form:
- solid
- Details on test material:
- - Name of test material (as cited in study report):Aluminium tristearate- Molecular formula :C18H36O2.1/3Al- Molecular weight: 877.3995 g/mol- Substance type:Organic- Physical state:Solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):Aluminum Stearate- Molecular formula (if other than submission substance):C18H36O2.1/3Al- Molecular weight (if other than submission substance):877.3995 g/mole- Substance type:Organic- Physical state:Solid
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality observed
- Mortality:
- When treated with 5000 mg/kg bw, No mortality were observed in treated rats.
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was considered to be > 5000 mg/kg bw when rats were treated with Aluminum tristearate orally.
- Executive summary:
In a acute roal toxicity study, rat were treated with aluminum trioctadecanoate in the concentration of 5000 mg/kg bw orally. No mortality were observed in treated rats at 5000 mg/kg bw when rats were treated with aluminum trioctadecanoate orally.
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