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EC number: 203-166-4 | CAS number: 104-01-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from NTIS study report.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Summary of toxicity studies for 4-METHOXYPHENYLACETIC ACID (MPAA)
- Author:
- National Technical Information Service
- Year:
- 1 991
- Bibliographic source:
- National Technical Information Service, OTS0530656-1 (1991)
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The eye irritation potential of 4-methoxyphenylacetic acid was assessed in rabbits according to the Draize method.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-methoxyphenylacetic acid
- EC Number:
- 203-166-4
- EC Name:
- 4-methoxyphenylacetic acid
- Cas Number:
- 104-01-8
- Molecular formula:
- C9H10O3
- IUPAC Name:
- 2-(4-methoxyphenyl)acetic acid
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material (as cited in study report):4 methoxy phenylacetic acid (MPAA)
- Molecular formula : C9H10O3
- Molecular weight : 166.175g/mol
- Smiles notation: c1(ccc(OC)cc1)CC(O)=O
- InChl : 1S/C9H10O3/c1-12-8-4-2-7(3-5-8)6-9(10)11/h2-5H, 6H2, 1H3, (H,10,11)
- Substance type: Organic
- Physical state: Solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 4-methoxyphenylacetic acid
- Molecular formula : C9H10O3
- Molecular weight : 166.175g/mol
- Smiles notation : c1(ccc(OC)cc1)CC(O)=O
- InChl : 1S/C9H10O3/c1-12-8-4-2-7(3-5-8)6-9(10)11/h2-5H, 6H2, 1H3, (H,10,11)
- Substance type: Organic
- Physical state: Solid
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- No data available
Test system
- Vehicle:
- physiological saline
- Controls:
- not specified
- Amount / concentration applied:
- 0.1gm
- Duration of treatment / exposure:
- 21 days
- Observation period (in vivo):
- 1hr ,1,2, 3,4 ,7,14and 21 days
- Duration of post- treatment incubation (in vitro):
- no data available
- Number of animals or in vitro replicates:
- 9 animals (one animal and 8 additional animals)
- Details on study design:
- TEST SITE: Right eye
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Yes with room temperature saline solution 30 seconds after application of test material.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 3 days
- Score:
- 71.2
- Max. score:
- 110
- Reversibility:
- not reversible
- Remarks on result:
- probability of severe irritation
- Irritant / corrosive response data:
- Discharge ,swelling ,redness between one hr and 3 days Cornal opacity, iritis and conjunctival irritation.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- 4-MethoxyphenyIacetic Acid (MPAA) was considered to be a very severe irritant to the eye of New Zealand White rabbits under the conditions of these studies causing effects which were not reversed within 21 days of treatment. Immediate washing of the eyes resulted in reduced irritation and more rapid recovery.
4-MethoxyphenyIacetic Acid (MPAA) may be classified under the category 2 (irritating to eyes). - Executive summary:
The eye irritation potential of 4-methoxyphenylacetic acid was assessed in rabbits according to the Draize method. The test was conducted on New Zealand White rabbits.
Test is first performed on one rabbit with 0.1gm of test substance, the treated eye showed moderate irritation, Thereafter 8 additional animals were tested and subjected to rinsing with normal saline after 30 seconds of administration .Ocular lesions were scored approx 1 hr, 1 day upto 21 days. Even 21 days after treatment, un-rinsed eyes in 5/6 treated animals displayed corneaI opacity, iritis and conjunctival irritation. The maximum mean irritation score was 71.2 (of 110 possible maximum) which occurred on day 3, the rinsed eyes showed milder effects; however, serious adverse effects persisted to day 21. 4-MethoxyphenyIacetic Acid (MPAA) was considered to be a very severe irritant to the eye of albino rabbits under the conditions of these studies causing effects which were not reversed within 21 days of treatment. Immediate washing of the eyes resulted in reduced irritation and more rapid recovery.
4-MethoxyphenyIacetic Acid (MPAA) may be classified under the category 2 (irritating to eyes).
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