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EC number: 944-459-3 | CAS number: -
Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- 151-21-3 (purity 25%)
- IUPAC Name:
- 151-21-3 (purity 25%)
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Kleinrusse
- Details on test animals or tissues and environmental conditions:
- According to Guideline.
Test system
- Vehicle:
- not specified
- Controls:
- not required
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- n.a.
- Observation period (in vivo):
- 21 days
- Number of animals or in vitro replicates:
- 4
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24+48+72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 21 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24+48+72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24+48+72 h
- Score:
- 2.6
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 21 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24+48+72 h
- Score:
- 1.1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
Any other information on results incl. tables
Cornea
time (hrs) time (days)
1 6 24 48 72 7 10 14 17 21
mean A 0.75 0.75 1 1 1 1 0.75 0.75 0.75 0.75
mean B 1.5 1.25 4 3.25 3.25 2.75 2.25 2.25 2.25 1.75
A = cloudiness grade
B = cloudiness surface
Cornea (0.5 % aqueous fluorescein): mean 100 or 40 after 24 hrs or 21 days p.a.
Conjunctivae
time (hrs) time (days)
1 6 24 48 72 7 10 14 17 21
mean A 1 2 2.25 2.75 2.75 2.25 1.5 1.25 1.25 1.25
mean B 1.25 1 1.25 1 1 0.5 0.25 0 0 0
mean C 3 3 3 3 3 1 2.25 1.75 1.75 0.75
A = erythema
B = chemosis
C = exsudation
Reversibility: no
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
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