Registration Dossier
Registration Dossier
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EC number: 204-376-9 | CAS number: 120-20-7
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- Method: BASF-test
- GLP compliance:
- no
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- 3,4-dimethoxyphenethylamine
- EC Number:
- 204-376-9
- EC Name:
- 3,4-dimethoxyphenethylamine
- Cas Number:
- 120-20-7
- Molecular formula:
- C10H15NO2
- IUPAC Name:
- 2-(3,4-dimethoxyphenyl)ethanamine
- Test material form:
- liquid
- Details on test material:
- - name of substance: homoveratrylamin
- Purity: 98 %
- substance number: 78/836
- appearance: clear, yellowish, slightly viscous liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: WIGA Versuchstierzuchtanstalt, Sulzfeld
- Weight at study initiation: 185 +/- 15 g
- Fasting period before study:
- Diet (e.g. ad libitum): Herilan MRH, H. Eggersmann KG, Rinteln/Weseer, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- air
- Details on inhalation exposure:
- - inhalation period: 4 h
- observation period: 14 days
- Exposure system: head-to-nose inhalation system (animals were fixed in tubes, only their snouts were in the area of exposure). - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 5,53 mg/L; maximal attainable concentration.
- No. of animals per sex per dose:
- 10
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5.5 mg/L air
- Exp. duration:
- 4 h
- Mortality:
- No mortalities.
- Clinical signs:
- other: Reddish secretion from eyes and nose, intermittent respiration, paddling movements, ruffled agglutinated fur.
- Body weight:
- Absolute body weights in males before inhalation/days after inhalation/14 days after inhalation: 187/213/259
Absolute body weights in females before inhalation/days after inhalation/14 days after inhalation: 181/197/217 - Gross pathology:
- No abnormalities.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 was > 5.5 mg/l with test substance homoveratrylamin.
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