3,4-dimethoxyphenethylamine

Endpoint summary

Description of key information

3,4-Dimethoxyphenethylamine (CAS 120-20-7) is acutely harmful to aquatic organisms, according OECD criteria.

Additional information

Ecotoxicity data for 3,4 -dimethoxyphenethylamine (CAS 120-20-7) are available only for fish (acute toxicity) and aquatic microorganisms. Therefore, (Q)SAR models were used to generate the data. In addition, a read-across approach was performed to two structurally similar substances (3,4 -dimethoxyphenylacetonitrile, CAS 93-17-4; 4 -allylveratrole,CAS 93-15-2).

The available data are listed in the table below.

Study	Results		Remarks
Short-term toxicity to fish:
3,4 -dimethoxyphenethylamine (CAS 120-20-7):
BASF AG, 1989, Rep. No.: 10F0747/885014	96 -h LC50 > 100 mg/L (pH-adjusted) 96 -h LC50 = 68 mg/L (not pH-adjusted)		Nominal, DIN 38412, L15, non-GLP
CAS 93-15-2
NITE / J-CHECK, 2003	LC50 = 14 mg/L		Measured, OECD 203, GLP
Environment Canada, 2010 (secondary source)	LC50 = 6 mg/L (Salmogairdneri) LC50= 8.1 mg/L (Lepomismacrochirus)		Disregarded due to significant methodological deficiencies: the solvent concentration is exceeding the acceptable level according to OECD 203. Original study performed in 1975
CAS 93-17-4
BASF AG, 1989, Rep. No.: 10F06668/885021	LC50 ≥ 100 mg/L		Nominal, DIN 38412, L15, non-GLP
Conclusion	3,4 -dimethyoxyphenethylamine (CAS 120 -20 -7) is with high probability acutely not harmful to fish.
Short-term toxicity to aquatic invertebrates
3,4-Dimethoxyphenethylamine (CAS 120-20-7)
ECOSAR v1.11	EC50 = 338 mg/L		In AD
US EPA T.E.S.T. v4.2.1	EC50 = 11.5 mg/L		In AD
VEGA v1.1.3: 1)   EPA v1.0.7 2)   DEMETRA v1.0.4	1)   EC50 = 2.5 mg/L 2)   EC50 = 9.8 mg/L		Out of AD
QSAR Toolbox v3.3.5.17: 1)   Trend Analysis 1 2)   Trend Analysis 2	1)   EC50 = 36.5 mg/L 2)   EC50 = 41.7 mg/L		In AD
CAS 93-15-2
NITE / J-CHECK, 2003	EC50 = 38 mg/L		Measured, OECD 202, GLP
CAS 93-17-4
BASF AG, Rep. No.:02/0651/50/1	EC50 > 100 mg/L		Nominal test concentrations
Conclusion	3,4-dimethoxyphenethylamine (CAS 120-20-7) is acutely harmful to aquatic invertebrates.
Long-term toxicity to aquatic invertebrates (not an information requirement)
CAS 93-15-2
NITE / J-CHECK, 2003	NOEC = 1.1 mg/L	Measured, OECD 211, GLP
Conclusion	Chronic effects of 3,4-dimethoxyphenethylamine (CAS 120 -20 -7) to aquatic invertebrates are not expected.
Toxicity to aquatic algae and cyanobacteria
3,4-Dimethoxyphenethylamine (CAS 120-20-7)
ECOSAR v1.11	EC50 = 338 mg/L ChV= 147 mg/L		Green algae, In AD
CAS 93-15-2
NITE / J-CHECK, 2003	ErC50 = 22 mg/L NOEC = 4.6 mg/L		Measured, OECD 201, GLP, Rh.subcapitata
CAS 93-17-4
BASF AG, 2003, Report No. 02/0651/60/1	ErC50 > 100 mg/L ErC10 = 41.8 mg/L NOEC = 25 mg/L		Nominal, OECD 201, GLP, Rh.subcapitata
Conclusion	3,4-Dimethoxyphenethylamine (CAS 120-20-7) is acutely harmful to aquatic algae and cyanobacteria.
Toxicity to microorganisms
3,4-Dimethoxyphenethylamine (CAS 120-20-7)
BASF AG, 1988, Rep. No.: 01.0401/88;	30-min EC20 > 1000 mg/L 30-min EC50 > 1000 mg/L		Nominal, ISO 8192, respiration inhibition, non-GLP
BASF AG, 1988, Rep. No.: 9/0844/88	17-h EC10 = 141 mg/L 17-h EC50 = 200 mg/l		Nominal, DIN 38412-8, P. putida, growth inhibition, non-GLP
CAS 93-17-4
BASF AG, 2005 Rep. No.: 02/0651/08/1	30-min EC20 = 230 mg/L 30-min EC50 = 800 mg/L		Nominal, OECD 209, respiration inhibition, GLP
Conclusion	The inhibition of the degradation activity of activated sludge is not anticipated when the 3,4-dimethoxyphenethylamine (CAS 120-20-7) is introduced in appropriately low concentrations

Algae turned out to be the most sensitive trophic level (72-h ErC50 = 22 mg/L, 4-Allylveratrole, CAS 93 -15 -2). According to the available data 3,4-dimethoxyphenethylamine (CAS 120-20-7) is considered to be acutely harmful to aquatic organisms