1-(2-methyl-4-(2-methylphenylazo)phenylazo)-2-naphthol

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Justification for type of information:

data is from safety assessment reports

Data source

Reference

Reference Type:

secondary source

Title:

REPORTS of the Scientific Committee on Cosmetology (seventh series)

Author:

Published by the COMMISSION OF THE EUROPEAN COMMUNITIES; Directorate-General Telecommunications, Information Industries and Innovation

Year:

1988

Bibliographic source:

Scientific Committee on Cosmetology (seventh series), 1988

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

To evaluate the dermal irritation potential of the test chemical

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

1-(2-methyl-4-(2-methylphenylazo)phenylazo)-2-naphthol

EC Number:

201-635-8

EC Name:

1-(2-methyl-4-(2-methylphenylazo)phenylazo)-2-naphthol

Cas Number:

85-83-6

Molecular formula:

C24H20N4O

IUPAC Name:

1-(2-methyl-4-(2-methylphenylazo)phenylazo)-2-naphthol

Specific details on test material used for the study:

Name of the test chemical: 1-({2-methyl-4-[(2-methylphenyl)diazenyl]phenyl}diazenyl)-2-naphthol (also known as Solvent Red 24)
Molecular formula: C24H20N40
Molecular weight: 380.48 g/mol
SMILES: Cc1ccccc1N=Nc1ccc(N=Nc2c3ccccc3ccc2O)c(C)c1
Substance Type: Organic
Physical State: Solid

Test animals

Species:

rabbit

Strain:

not specified

Details on test animals or test system and environmental conditions:

no data available

Test system

Type of coverage:

not specified

Preparation of test site:

not specified

Vehicle:

other: 0.5 ml 1,2-propanediol

Controls:

not specified

Amount / concentration applied:

500 mg

Duration of treatment / exposure:

not specified

Observation period:

not specified

Number of animals:

not specified

Details on study design:

not specified

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

other: not specified

Score:

2.3

Reversibility:

not specified

Remarks on result:

probability of mild irritation

Irritant / corrosive response data:

Slightly irritating to rabbit skin.

Applicant's summary and conclusion

Interpretation of results:

Category 2 (irritant) based on GHS criteria

Conclusions:

The irritation index was determined to be 2.3. Based on the scores, the test chemical can be considered as slightly irritating to rabbit skin.

Executive summary:

Skin irritation test was carried out on rabbits with 500 mg of the test chemical in 0.5 ml 1,2-propanediol, and the irritation effects were observed (duration not specified) and scored.

The irritation index was determined to be2.3. Based on the scores, the test chemical can be considered as slightly irritating to rabbit skin.