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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
2007
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2007
Report date:
2007

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Annex V.A.1 of the Regulation on Notification of New Substances and the Classification, Packaging and Labelling of Hazardous Substances.
Type of method:
HPLC method

Test material

1
Chemical structure
Reference substance name:
5,11-dihydro-11-((4-methyl-1-piperazinyl)acetyl)-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one monohydrochloride
EC Number:
812-545-9
Cas Number:
93173-05-8
Molecular formula:
C19H21N5O2 x HCl
IUPAC Name:
5,11-dihydro-11-((4-methyl-1-piperazinyl)acetyl)-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one monohydrochloride
Test material form:
solid: bulk

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Key result
Type:
log Pow
Partition coefficient:
2
Remarks on result:
other:
Remarks:
no pH value and temperature are provided

Applicant's summary and conclusion

Conclusions:
To compare the partition coefficient with the maximum of substances, the result oflogP = 2.0 obtained in the analysis conducted with the methanol:water mobile phase isconsidered valid, as this condition is shared by all the tested substances.