4-aminonaphthalene-1,8-dicarboximide

Endpoint summary

Additional information

Short-term toxicity to fish:

Predicted model data and experimental study result for the test chemical 4-aminonaphthalene-1,8-dicarboximide (CAS No. 1742-95-6) with respective read across were reviewed to summarize the following information:

In key study the 96 hrs aquatic toxicity study was predicted to assess toxic effects of the test compound 4-aminonaphthalene-1,8-dicarboximide (CAS No. 1742-95-6)and the result were predicted (SSS QSAR Prediction model, 2016). The study was based on the effects of the test compound on Danio rerio fish in a static fresh water system. The predicted data suggests the lethal concentration (LC50) for the test compound was estimated to be 321.484771729 mg/l on the basis of mortality effect.

Whereas supporting model which is based on the QSAR prediction done using the EPI Suite ECOSAR version 1.10 (EPI Suite, 2016), the 96 hours LC50 was estimated to be 1179.148 mg/l on fish for substance 4-aminonaphthalene-1,8-dicarboximide (CAS No. 1742-95-6) with mortality effects.

Above predicted lethal concentrations for target chemical supported by experimental study for read across chemical Phthalimide (Cas no. 85-41-6) which is indicates that acute toxicity test of Phthalimide to Oryzias latipes according to OECD Guideline 203 (Fish, Acute Toxicity Test) the dose concentration- control, 55.6 mg/L, 100.0 mg/L (nominal concentrations) was used at 24±1 degreeC test temp.,6.6 - 7.1 pH and 5.1 - 11.0 mg/l (Saturated concentration at 24 °C is 8.25 mg/l) dissolved oxygen in semi static freshwater condition for 96 hrs.

During experiment the lethal concentration (LC50) was found to be 100 mg/l with 95% confidence limit of 55.6 ->100 mg/l.(Japan chemicals collborative knowledge database (J-check); 2016)

Thus, based on above all lethal concentration values, it can be concluded that the target chemical 4-aminonaphthalene-1,8-dicarboximide (CAS No. 1742-95-6) can be considered as non-toxic to aquatic organisms and thus cannot be classified as hazardous as per the CLP criteria.

Short term toxicity to aquatic invertebrates:

Predicted studies for the 4-Amino-1,8-naphthalimide were reviewed to summarize the following information:

In 48 hrs aquatic toxicity studies (EPI suite, ECOSAR version 1.1, 2016) were conducted to assess toxic effects of the 4-Amino-1, 8-naphthalimide (CAS no 1742-95-6) and the results were predicted. The study was based on the effects of the test compound on the Daphnia magna in a static fresh water system. The predicted data suggests the lethal concentration (LC50) for the 4-Amino-1, 8-naphthalimide (CAS no 1742-95-6) was estimated to be 614.752 mg/L.

Another prediction model for aquatic toxicity (SSS QSAR prediction model, 2016) were conducted to assess toxic effects of the 4-Amino-1, 8-naphthalimide (CAS number: 1742-95-6).The study was conducted on the Daphnia magna in a static fresh water system. The predicted data suggests the effective concentration (EC50) for 4-Amino-1, 8-naphthalimide (CAS number: 1742-95-6) was estimated to be 108.003410339 mg/l on the basis of intoxication.

On the basis of results of prediction report on toxicity to aquatic invertebrates , it can be considered that 4-Amino-1,8-naphthalimide is not likely to be toxic to aquatic invertebrates at environmentally relevant concentrations and can be considered as not hazardous to aquatic biota.

Toxicity to microorganisms:

Predicted model data and experimental study result for the test chemical 4-aminonaphthalene-1,8-dicarboximide (CAS No. 1742-95-6) with respective read across were reviewed to summarize the following information:

In key study the 48 hrs aquatic toxicity study was predicted to assess toxic effects of the test compound 4-aminonaphthalene-1,8-dicarboximide (CAS No. 1742-95-6)and the result were predicted (SSS QSAR Prediction model, 2016). The study was based on the effects of the test compound on Tetrahymena pyriformis (Bacteria) in a static fresh water system. The predicted data suggests the Inhibition growth concentration (IGC50) for the test compound was estimated to be 356.234008789 mg/l on the basis of growth inhibition effect.

Above predicted inhibition concentration for target chemical supported by experimental study for read across chemical Phthalimide (Cas no. 85-41-6) which is indicates that effect concentration i.e EC0 on the basis of inhibition of cell inhibition for 16 hrs. was found to be 260 mg/l. (SIDS INITIAL ASSESSMENT PROFILE;2005 and INERIS database,2005)

Thus, based on above all effect values, it can be concluded that the target chemical 4-aminonaphthalene-1,8-dicarboximide (CAS No. 1742-95-6) can be considered as non-toxic to micro organisms.

Toxicity to aquatic algae and cyanobacteria

Various predicted data for the target chemical 4-Amino-1,8-naphthalimide(CAS No. 1742-95-6) and the study of its read across substance were reviewed to summarize the following information:

72 hrs aquatic toxicity study was predicted to assess toxic effects of the test compound 4-Amino-1,8-naphthalimide (CAS no.1742 -95 -6) and the result were predicted (SSS QSAR Prediction model, 2016). The study was based on the effects of the test compound on Desmodesmus subcapitata in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the test compound 4-Amino-1,8-naphthalimide (CAS no.1742 -95 -6) was estimated to be222.021 mg/l on the basis of growth rate.

 

Based on the QSAR prediction done using the EPI Suite ECOSAR version 1.10, the 96 hours EC50 was estimated to be 321.762 mg/l on green algae for substance 4-Amino-1,8-naphthalimide with growth inhibition effects.

Short term toxicity to algae study was carried out for 72 hrs (J-CHECK, 2016). Based on growth rate of the test organism algae, the 72 hrs EC50 value was determined to be > 150 mg/l.

Short term toxicity toSelenastrum capricornutumstudy was carried out for 72 hrs (SIDS INITIAL ASSESSMENT PROFILE, SIAM 20, 19-21 April 2005). The test organism used for the study was Selenastrum capricornutum.The 72 hrs ExC50 value for Selenastrum capricornutum was determined to be 161 mg/l.

Based on the overall reported results for target and read across substance, it can be concluded that the substance 4-Amino-1,8-naphthalimide can be considered as non-toxic to aquatic organisms and thus cannot be classified as hazardous as per the CLP criteria.