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EC number: 217-110-1 | CAS number: 1742-95-6
Endpoint summary
Administrative data
Description of key information
Additional information
Adsorption / desorption:
Experimental and Predicted data of adsorption endpoint for the target chemical 4-aminonaphthalene-1,8-dicarboximide (Cas no. 1742-95-6) and its read across chemical were reviewed to summarize as follows:
From predicted model EPI suite 2016 indicate that the soil adsorption coefficient (Koc) value of chemical 4-aminonaphthalene-1,8-dicarboximide is estimated to be 24.82 L/kg (log KOC = 1.3948) by means of MCI method at 25 deg.C, indicating that it is has a Negligible sorption to soil and sediment and therefore have rapid migration potential to groundwater.
Whereas from chemspider predicted database the soil adsorption coefficient i.e Koc value of test substance 4-aminonaphthalene-1,8-dicarboximide was estimated to be 68.40 L/Kg i.e Log Koc= 1.835 at pH 5.5 and 67.90 L/Kg i.e Log Koc= 1.831 at pH 7.4. This Koc value indicates that the substance 4-aminonaphthalene-1,8-dicarboximide has a Negligible sorption to soil and sediment and therefore have rapid migration potential to groundwater.
And read across Phthalimide (Cas no. 85-41-6)experimental study from HSDB authorative database indicate that the adsorption coefficient (Koc) of substance Phthalimide was found to be 100 using an experimental log Kow of 1.15 and a regression-derived equation. This Koc value suggests that phthalimide should have high mobility in soil.
Thus based on the above all studies it is concluded that the test substance 4-aminonaphthalene-1,8-dicarboximide (Cas no. 1742-95-6) has a Negligible sorption to soil and sediment i.e have high mobility to soil/ sediment.
Biodegradation in water
The predicted data for the test compound4-Amino-1,8-naphthalimide(CAS No. 1742-95-6) and the study for its read across substance were reviewed for the biodegradation end point which are summarized as below:
Estimation Programs Interface Suite (EPI suite, 2016) was run to predict the biodegradation potential of the test compound 4-Amino-1,8 -naphthalimid e (CAS no. 1742-95-6) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradatio n Timeframe, MITI LInear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that 4-Amino-1,8-naphthalimide is not expected to be readily biodegradable.
Biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test substance1,5-Naphthalenediamine (J-CHECK, 2016). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l. The percentage degradation of test substance was determined to be 0% by BOD and 3% by HPLC in 28 days. Thus, the substance1,5-Naphthalenediamine is not considered to be readily biodegradable in water.
Biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test substance1-Naphthylamine (J-CHECK, 2016). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l. The percentage degradation of test substance was determined to be 0% by BOD and 3% by HPLC in 28 days. Thus, the substance1-Naphthylamine is not be considered to be readily biodegradable in water.
Biodegradation study was conducted for evaluating the percentage biodegradability of test substance1-Naphthylamine (Environmental Fate Data Base, 2016). Concentration of inoculum i.e, activated sludge used was 100 mg/l and initial test substance conc. used in the study was 200 mg/l. The percentage degradation of test substance was determined to be 0% by COD removal in 5 days at a temperature of 20°C. Thus, the substance 1-Naphthylamine is not considered to be readily biodegradable in water.
Biodegradation study was conducted for evaluating the percentage biodegradability of test substance1-Naphthylamine (George W. Malaney, 1960). Aniline-acclimated sludge was used as a test inoculum. The original source of microorganisms was mixed liquor from the aeration tank of a municipal treatment plant. Biodegradation of test chemical was tested by the conventional Warburg technique, using 125 ml flasks. Concentration of inoculum i.e, sludge used was 2,500 mg/l and initial test substance conc. used in the study was 500 mg/l. Incubation of the test vessel was carried out at 20ᵒC for 5-8 days i.e, 120-192 hrs. The percentage degradation of test substance was determined to be 0% by BOD and 3% by HPLC in 28 days. Oxidation in the test flask was recorded as mg O2 uptake per liter of the mixture in the flask. The mg of O2 uptake by the test substance1-Naphthylaminewas determined to be 890 mg/l and the percentage degradation of the test substance was determined to be 23% by BOD in 8 days. Thus, the substance1-Naphthylamine is not expected to be readily biodegradable in water.
Biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test substance 1,8-Naphthalenediamine (J-CHECK, 2016). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l. The percentage degradation of test substance was determined to be 0% by BOD, 9% by TOC removal and 1% by HPLC in 28 days. Thus, the substance 1,8-Naphthalenediamine is not considered to be readily biodegradable in water.
On the basis of above results for target and read across substance, it can be concluded that the test substance compound4-Amino-1,8-naphthalimidecan be expected to be not readily biodegradable in nature.
Biodegradation in water and sediment
Estimation Programs Interface (EPI) Suite (2016) prediction model was run to predict the half-life in water and sediment for the test compound4-Amino-1,8-naphthalimide (CAS No. 1742 -95 -6). If released in to the environment, 27.3 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of4-Amino-1,8-naphthalimidein water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the exposure risk to aquatic animals is moderate to low whereas the half-life period of4-Amino-1,8-naphthalimidein sediment is estimated to be 337.5 days (8100 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.0843%), indicates that4-Amino-1,8-naphthalimideis not persistent in nature.
Biodegradation in soil
The half-life period of 4-Amino-1,8-naphthalimide (CAS No. 1742 -95 -6)in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2016. If released into the environment, 72.6% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 4-Amino-1,8-naphthalimidein soil is estimated to be 75 days(1800 hrs). Based on this half-life value of 4-Amino-1,8-naphthalimide, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
On the basis of available information, the test substance 4-Amino-1,8-naphthalimide cannot be considered to be readily biodegradable in nature.
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