Registration Dossier

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
secondary source
Title:
IUCLID DATASET
Author:
EUROPEAN COMMISSION – European Chemicals Bureau
Year:
2000
Bibliographic source:
IUCLID DATASET- EUROPEAN COMMISSION – European Chemicals Bureau, 19–FEB–2000

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Skin irritation study of 4,4'-Diamino-2,2'-stilbenedisulfonic acid was conducted in rabbits to determine its irritation potential .
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Test material form:
not specified
Details on test material:
- Name of test material (as cited in study report):4,4'-Diamino-2,2'-stilbenedisulfonic acid
- Molecular formula (if other than submission substance):C14H14N2O6S2
- Molecular weight (if other than submission substance):370.405 g/mol
- Smiles notation (if other than submission substance):S(=O)(=O)(O)c1cc(N)ccc1C=Cc2ccc(N)cc2S(=O)(=O)O
- InChl (if other than submission substance):1S/C14H14N2O6S2/c15-11-5-3-9(13(7-11)23(17,18)19)1-2-10-4-6-12(16)8-14(10)24(20,21)22/h1-8H,15-
16H2,(H,17,18,19)(H,20,21,22)/b2-1+
- Substance type:Organic
- Physical state:solid

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
No Data Available
Duration of treatment / exposure:
No Data Available
Observation period:
No Data Available
Number of animals:
No Data Available
Details on study design:
No Data Available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: No Data Available
Reversibility:
no data
Remarks on result:
other: non irritant

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The test material 4,4'-Diamino-2,2'-stilbenedisulfonic acid (CAS No:81-11-8)was found to be non irritant to the rabbits’ skin.
Executive summary:

The skin irritation study of, 4’-Diamino-2,2'-stilbenedisulfonic acid (CAS No:81-11-8) was performed in rabbits to determine its irritation potential .

 

 Since no irritation was noted the test material 4,4'-Diamino-2,2'-stilbenedisulfonic acid was found to be non irritant on rabbits’ skin.