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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from Authorized database

Data source

Reference
Reference Type:
other: Authorized database
Title:
Acute oral toxicity of 1-Naphthalenesulfonic acid, 5-amino- in rats
Author:
United States trademark owned and licensed under authority of the U.S. Government
Year:
2016
Bibliographic source:
Registry of Toxic effects of chemical (RTECS), 2016

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
other: as below
Principles of method if other than guideline:
Acute oral toxicity of 1-Naphthalenesulfonic acid, 5-amino- in rats
GLP compliance:
not specified
Test type:
other: No data
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 1-Naphthalenesulfonic acid, 5-amino-
- Molecular formula (if other than submission substance): C10H9NO3S
- Molecular weight (if other than submission substance): 223.26 g/mole
- Substance type: Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality observed
Mortality:
No mortality observed in rats
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50 was considered to be > 5000 mg/kg bw when rats were treated with 1-Naphthalenesulfonic acid, 5-amino- orally.
Executive summary:

In acute oral toxicity, rats treated with1-Naphthalenesulfonic acid, 5-amino- in the concentration of 5000 mg/kg bw orally. No mortality observed in rats. Therefore,LD50 was considered to be > 5000 mg/kg bw when rats were treated with 1-Naphthalenesulfonic acid, 5-amino- orally.