Registration Dossier
Registration Dossier
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EC number: 226-133-6 | CAS number: 5292-43-3
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
The substance did not increase the number of revertant colonies in each of the five tested strains (TA1535, TA1537, TA98, TA100, TA102).
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The test was performed according to OECD 471 (1983). The mutation assay was conducted on five different bacterial strains (TA100, TA1535, TA102, TA98, TA1537) in two independent experiments. Six test article concentrations, in triplicate, were tested (15, 50, 150, 500, 1500, 5000 µg/plate). Test substance caused visible reduction in the growth of the bacterial background with and without S9 initially at 1500 µg/plate.
No biologically significant increase in the no. of revertant colonies were recorded for any bacterial strains, with any dose and either with or without S9. A very small increase in revertant was noted in tester strain TA100 with S9 at 500 µg/plate and only in the first experiment. This response was considered to be of no biological relevance since it was non-reproducible.
Justification for classification or non-classification
Considering the avaiable information, it can be concluded that the criteria for classification under the Regulation EC 1272/2008 (CLP) are not met.
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