Registration Dossier
Registration Dossier
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EC number: 225-918-0 | CAS number: 5146-66-7
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
3,7-dimethylocta-2,6-dienenitrile is rapidly absorbed and distributed to the tissues. It was detected in lung, liver, kidney, adrenals, ovaries and testes. 3,7-dimethylocta-2,6-dienenitrile is metabolized forming alcohol, the aldehyde, the acid, and an epoxide an and conjugated to glucuronide, glutathione, and amino acids. It is excreted mainly via urine and feces. Since minimum residues (<2% of the dose) were retained in tissues by 48 hours after dose administration, the bio-accumulation potential is expected to be low.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
In an in vivo study conducted on male and female mice (CD-1), which received single oral administration (gavage) of 300 or 600 mg/kg bw (bw) of the chemical in corn oil;3,7-dimethylocta-2,6-dienenitrile was metabolized forming alcohol, the aldehyde, the acid, and an epoxide an and conjugated to glucuronide, glutathione, and amino acids. It was excreted out of the living system mainly via urine and feces. Since minimum residues (<2% of the dose) were retained in tissues by 48 hours after dose administration, the bio-accumulation potential of the chemical is expected to be low.
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