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Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
16 May 1988 to 03 June 1988
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Deviations:
no
GLP compliance:
no
Specific details on test material used for the study:
Name: FAT 20136/B
Purity: 78 %
Analytical monitoring:
no
Vehicle:
yes
Remarks:
water
Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)
Details on test organisms:
10 animals per concentration.
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Test temperature:
23 °C
pH:
8
Nominal and measured concentrations:
30, 100, 300 and 1000 mg/L
Reference substance (positive control):
no
Duration:
96 h
Dose descriptor:
LC0
Effect conc.:
30 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
68.49 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LC100
Effect conc.:
300 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Details on results:
No mortality was seen at 30 mg/L. At 100 mg/L, 4/10 fish survived, while no mortality was observed at 300 and 1000 mg/L.
Validity criteria fulfilled:
no
Conclusions:
The LC50 of FAT 21036/B in this fish acute toxicity test was determined to be 68.49 mg/L.
Executive summary:

The acute fish toxicity test was performed according to a methodology similar to OECD Guideline 203 (CIBA method A-11). Zebrafish: (Danio rerio) were used in the experiment. 10 fish per concentration were tested at the concentrations of: 30, 100, 300 and 1000 mg/L. No mortality was seen at 30 mg/L. At 100 mg/L, 4/10 fish survived, while no mortality was observed at 300 and 1000 mg/L. Hence, the LC50 of FAT 21036/B in this fish acute toxicity test was determined to be 68.49 mg/L.

Description of key information

In a key acute fish toxicity test was performed according to a methodology similar to OECD Guideline 203 (CIBA method A-11). Zebrafish: (Danio rerio) were used in the experiment. 10 fish per concentration were tested at the concentrations of: 30, 100, 300 and 1000 mg/L. No mortality was seen at 30 mg/L. At 100 mg/L, 4/10 fish survived, while no mortality was observed at 300 and 1000 mg/L. Hence, the LC50 of FAT 21036/B in this fish acute toxicity test was determined to be 68.49 mg/L. In a supporting study conducted with similar methodology, the TL50 was determined to be 6.3 mg/l.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
68.49 mg/L

Additional information