Registration Dossier
Registration Dossier
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EC number: 279-365-5 | CAS number: 80010-51-1
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 Oct 2015 to 26 Nov 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Identification: FAT 21036/G TE Lot: AT-0033945200
Appearance: Dark blue powder - Analytical method:
- photometric method
- Key result
- Type:
- Pow
- Partition coefficient:
- 3.92
- Temp.:
- 20 °C
- Remarks on result:
- other: pH is not available
- Key result
- Type:
- log Pow
- Partition coefficient:
- 0.58
- Temp.:
- 20 °C
- Remarks on result:
- other: pH is not available
- Conclusions:
- The n-octanol/water partition coefficent (log Pow) of the test item at 20 °C was determined to be 0.58.
- Executive summary:
The n-octanol/water partition coefficient of the test item was evaluated in a study conducted according to the EU Method A.8, OECD Guideline 107 and OECD Guideline 117. the shake-flask method was used for this purpose. Based on the findings of the study, the n-octanol/water partition co-efficient (log Pow) of FAT 21036/G at 20 °C was determined to be 0.58 (Pow = 3.92 ).
Reference
Preliminary Visual Estimation of the n-octanol solubility:
an amount of the test item was stirred with different amounts of n-octanol at room temperature and visually checked for any undissolved particles.
Amount of test item in mg |
Volume in mL |
Total volume in mL |
Stirring time |
Appearance of mixture |
10 |
1 |
1 |
60 min |
undissolved |
10 |
2 |
3 |
60 min |
undissolved |
10 |
2 |
5 |
60 min |
undissolved |
10 |
2 |
7 |
60 min |
dissolved |
Determination of the solubility in n-Octanol phase: Flask Method
Experiment |
A |
B |
C |
D (blank) |
Amount of test item (mg) |
1000 |
1000 |
1000 |
-- |
Stirring time at 30 °C (h) |
24 |
48 |
72 |
72 |
Measured concentration (mg/L) |
9.1 |
9.3 |
10.1 |
-- |
Dilution |
0.05mL/10mL |
0.05mL/10mL |
0.05mL/10mL |
-- |
n-Octanol solubility (g/L) |
1.83 |
1.87 |
2.03 |
-- |
Average experiments A to C: 1.91 g/L
Description of key information
The n-octanol/water partition coefficient of the test item was evaluated in a study conducted according to the EU Method A.8, OECD Guideline 107 and OECD Guideline 117. The shake-flask method was used for this purpose. Based on the findings of the study, the n-octanol/water partition co-efficient (log Pow) of FAT 21036 at 20 °C was determined to be 0.58 (Pow = 3.92 ).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 0.58
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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