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Physical & Chemical properties

Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2016
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) - Method B: Fibre Length and Diameter Distributions
Deviations:
no
Principles of method if other than guideline:
In consideration of the relevance of granulometry on toxicological assessment, only the size distribution of the sieved fraction < 100 µm were studied in detail.
GLP compliance:
no
Type of method:
determination of fibre length and diameter distributions
Type of distribution:
volumetric distribution
Mass median aerodynamic diameter:
66.88 µm
Key result
Percentile:
D50
Mean:
66.88 µm
Remarks on result:
other: no further data
No.:
#1
Size:
>= 5 - <= 100 µm
Distribution:
99.36 %
Remarks on result:
other: of the sieve fraction < 100 µm
No.:
#2
Size:
> 100 µm
Distribution:
0.64 %

Result: Sieve Fraction (<100µm):

- weighted sample: 0.7169 g

- weight fraction <100µm: 0.1554 g

- mass fraction <100µm: 21.68 %

The mass fraction <100µm was 21.68 %, and was investigated by scanning electron microscopy. The mean diameter (median) was 32.80 µm with 18.47µm standard deviation. The median aspect ratio (median) was 1.850 with 0.92 as standard deviation.

The median diameter (mass fraction) of the particle size is given for the fraction <100µm. The value 66.88µm was calculated for spherical and the value 57.67µm was calculated for cubical particles.

 Particle Size  Spherical Volume [%]  Cubical Volume [%]
 <4 µm (respirable)  0.00  0.00
 4-10 µm (thoracic)  0.00 0.00
 10-100 µm (inhalable)  92.74  96.95
 >100 µm  7.26 3.05
 Median (diameter µm) 66.88 
 
 57.67
Conclusions:
The Mean-Mass Aerodynamic Diameter is 66.88 µm as determined by Scanning Electron Microscopy.
Executive summary:

The Mean-Mass Aerodynamic Diameter is 66.88 µm as determined by Scanning Electron Microscopy.

Description of key information

The Mean-Mass Aerodynamic Diameter is 66.88 µm as determined by Scanning Electron Microscopy.

Additional information