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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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 Sprague-Dawley rats weighing 200-225 g were maintained on tap water and standard lab feed ad libitum in a 12-h light-dark cycle for 3 d prior to treatment. PCT, 0.5, 1, or 1.5 g/kg, was administered to rats in preservative-free soybean oil (4 ml/kg, ip). Animals were killed by cervical dislocation 1, 4, or 12 h after solvent injection. Lungs and livers were perfused in situ with 0.9% saline (25°C) until lungs were pink to white in colorand, PCT concentrationsin lungs and livers were measured.





p-chlorotoluene, 500, 1000, or 1500 g/kg were administrated to rat in preservative-free soybean oil (4 ml/kg, ip). 
Animals were killed 1, 4, or 12 h after solvent injection. Lungs and livers were perfused and p-chlorotoluene 
concentrations in lungs and livers were measured.When p-chlorotoluene (1000 mg/kg, ip) was given to rats, blood 
and lung levels rose rapidly at 1 h and, for the time points tested, reached near maximum levels at 1 h and started 
to decline at 4 h. Lowest solvent tissue levels were observed at 12 h.

In another study rabits received via gavage a single oral administration of 300 mg/kg bw of p-chlorotoluene. 
64 -83% of the dose was excreted with the urine as ether-soluble p-chlorbenzoic acid derivatives; 1% of the 
dose was found in the urine as ester glucuronides.
 
In the urine of dogs the corresponding huppuric acid was found