Registration Dossier
Registration Dossier
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EC number: 203-397-0 | CAS number: 106-43-4
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: special study
Data source
Reference
- Reference Type:
- publication
- Title:
- The in vitro effects of selcted environmental toxicants on two heme synthesis enzymes
- Author:
- Johnson DJ, Williams HL, Slater S, Haut MJ, Altstatt LB
- Year:
- 1 985
- Bibliographic source:
- J Environ Pathol Toxicol Oncol 6, 211-218
Materials and methods
- Type of study / information:
- haemotoxicity in vitro
- Principles of method if other than guideline:
- The effect of p-chlorotoluene on heme synthesis in vitro was examined by studying the influence of tis compound on delta-amino/evulinic acid synthetase (ALAS) and ferrochelatase (FC) activities in rat liver homogenates.
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-chlorotoluene
- EC Number:
- 203-397-0
- EC Name:
- 4-chlorotoluene
- Cas Number:
- 106-43-4
- Molecular formula:
- C7H7Cl
- IUPAC Name:
- 4-chlorotoluene
- Details on test material:
- p-chlorotoluene ws purchased from the Aldrich Chemical company, Milwaukee, WI 53233
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Executive summary:
- The effect of p-chlorotoluene on heme synthesis in vitro was determined by studying its influence on delta-amino-levulinic acid synthetase (ALAS) and ferrochelatase (FC)activities in rat liver homogenates; at a final concentration of 0.001 mol/l (= 126 ug/ml), p-chlorotoluene induced a very slight inhibition of ALAS activity (activity, expressed as percentage of control: 97 %), whereas the activity of FC remained unaffected by p-chlorotoluene.
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