Registration Dossier
Registration Dossier
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EC number: 201-166-9 | CAS number: 79-00-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1969
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: The method, test conditions and design were not sufficiently detailed.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-finding|toxicity data: list VII
- Author:
- Smyth, H.F., Carpenter, C.P., Weil, C.S., Pozzani, U.C.,|Striegel, J.A., Nycum, J.S.
- Year:
- 1 969
- Bibliographic source:
- American Ind. Hgy. Assoc. J., 30|(5):470-476.
- Reference Type:
- publication
- Title:
- Range-finding|toxicity data: list VII
- Author:
- Smyth, H.F., Carpenter, C.P., Weil, C.S., Pozzani, U.C.,|Striegel
- Year:
- 1 962
- Bibliographic source:
- American Ind. Hgy. Assoc. J., 23: 95-107
Materials and methods
- Principles of method if other than guideline:
- Method: Draize test briefly described in the publication of Smyth (1962). Observation following 24-h application of 0.01 mL of test substance on rabbit skin.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,1,2-trichloroethane
- EC Number:
- 201-166-9
- EC Name:
- 1,1,2-trichloroethane
- Cas Number:
- 79-00-5
- Molecular formula:
- C2H3Cl3
- IUPAC Name:
- 1,1,2-trichloroethane
- Details on test material:
- Name of the test substance (as cited in the test report) : 1,1,2-trichloroethane.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Test system
- Type of coverage:
- open
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.01 mL
- Duration of treatment / exposure:
- 1 day
- Observation period:
- 14 day
- Number of animals:
- no data
- Details on study design:
- no data
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Time point:
- other: 24 h
- Score:
- 2
- Max. score:
- 10
- Reversibility:
- fully reversible
- Irritant / corrosive response data:
- Slight capillary congestion was observed after single non occlusive application of 0.01 ml 1,1,2-trichloroethane (14.4 mg).
- Other effects:
- no data
Any other information on results incl. tables
no data
Applicant's summary and conclusion
- Conclusions:
- Under test conditions, the test item was found to be slightly irritating (irritation score: 2/10).
- Executive summary:
Skin irritation testing was performed using Draize test briefly described in the publication of Smyth (1962). Observation was performed following 24-h application of 0.01 mL of test substance on rabbit skin. Application site was not covered following application.
Under test conditions, the test item was found to be slightly irritating (irritation score: 2/10).
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