Registration Dossier
Registration Dossier
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EC number: 201-166-9 | CAS number: 79-00-5
Endpoint summary
Administrative data
Description of key information
Acute toxicity (LD50) of 1,1,2-trichloroethane is 837 mg/kg by oral administration in rats and 9 g/m3 /6hr by inhalation in rats.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 837 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 9 000 mg/m³ air
Additional information
For acute oral toxicity, 2 studies were available. One was with mice leading to an LD50 values of 378 mg/kg bw (White et al., 1985). The other one was conducted with rats (Smyth et al., 1969) leading to an LD50 value of 837 mg/kg bw. The LD50 obtained from the rat study was considered as the most relevant as acute studies with rats are considered as more robust or most representative of the toxicity observed in humans.
For acute dermal toxicity, no consistent results were found in the literature, and therefore this endpoint could not be definitely addressed. Two results were obtained with rabbit (Smyth et al., 1969) and Guinea pig (Wahlberg 1976), leading to an LD 50 of 5.38 g/kg bw and a LD 100 of 232 mg/cm2 respectively.
For acute inhalation toxicity, three results were obtained with mice, leading to LC 50 values of 2.3 g/m3, and LC0 of 4.42 and 2.3 g/m3, with mice exposed for 6, 3 and 4 hours, respectively. Two results were obtained with rats, leading to an LC50 of 9 g/m3 (Bonnet, 1980), with rats exposed for 6 hours and a LC60 of 2.7 g/m3, with rats exposed for 8 hours (Smyth, 1969).
The studies with rats were used for the definition of the key parameters.
Justification for classification or non-classification
Both LD50 oral values were in general agreement and result obtained with rats were considered in line with the current harmonized classification.
The acute dermal toxicity results were not considered reliable. The results for the two studies indicated a low hazard related to acute dermal toxicity. Nevertheless the current harmonized classification is not challenged.
The acute inhalation toxicity values were in general agreement. Based on the key value of 9 mg/l, classification for acute inhalation toxicity as category 3 appears more appropriate.
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