Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 938-351-5
CAS number: -
no other information
The acute skin irritation properties of isophorone diisocyanate
cyclodimer were estimated according to OECD method 404. A dose of 0.5 ml
test item per animal was applied to the clipped, intact dorsal and
lateral skin of 3 male rabbits under occlusive conditions. After the 4
-hour exposure period remains of test substance were removed with warm
water and skin irritation was assessed using the Draize scale. The
average scores at 60 min, 24, 48 and 72 hours after patch removal are as
follows: erythema: 2.56, edema: 1.11. The mean irritation index was
3.09. At the end of the post observation period (14 days) eschars were
observed. Therefore, under the conditions of this study isophorone
diisocyanate cyclodimer is moderately irritating to skin and must be
classified as irritating to skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again