(Z)-N-(3-aminopropyl)-N'-9-octadecenylpropane-1,3-diamine

Endpoint summary

Additional information

Based on a measured log Kow of -0.3 for both the Oleyltetramine and cocotriamine using the slow-stirring method (OECD 123) a BCF is calculated of 3.162 L/kg ww forthe alkyl-dipropylene triamines and tripropylene tetramines assuming no metabolism.

In vitro biotransformation by rainbow trout hepatic subcellulair fraction has been observed for primary alkyl amines and alkyl propane-1,3 -diamines. It is therefore likely that also alkyl dipropylene triamines and alkyl tripropylene tetramines are biotransformed.

The calculated BCF indicates a low bioaccumulation potential. These substances are almost completely protonated under ambient conditions. In addition, the bioavailable fraction of these substances is quickly degraded and a chronic exposure to a significant concentration is therefore unlikely. The predicted low bioaccumulation potential is supported by the low acute to chronic ratio observed in the long-term daphnia tests with these substances. The daphnia reproduction tests in general show that for alkyl polyamines that at one concentration step below the concentration where all parental daphnids were immobile, no detrimental effect on reproduction is observed when compared to the control. These observations indicate in a low acute-to-chronic ratio. A low acute-to-chronic ratio is indicative of a non-specific mode of action and is often associated with not systemic effects. This observation is consistent with the known effects of cationic surfactants on aquatic organisms, where toxicity is associated with physical binding to respiratory membranes. This explains the steep concentration curves seen and the lack of intermediate chronic effects on reproduction. Finally is the biodegradability a strong indication that these substances are also metabolized in fish.