Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Developmental toxicity / teratogenicity

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Administrative data

Endpoint:
developmental toxicity
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: US National Library of Medicine Hazardous Substances DataBank citation for Dexamethasone (CASRN 50-02-2). Review of published literature citation.

Data source

Reference
Reference Type:
secondary source
Title:
No information
Year:
2009
Bibliographic source:
US National Library of Medicine Hazardous Substances DataBank citation for Dexamethasone (CASRN 50-02-2). Review of published literature citation.

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Dexamethasone. Details on composition and concentration not provided.

Results and discussion

Results (fetuses)

Fetal abnormalities

Abnormalities:
not specified

Overall developmental toxicity

Developmental effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
Oral dexamethasone administration during pregancy was shown to result in maternal toxicity in rats and developmental effects (cleft palate & bone malformations) in pups