Registration Dossier
Registration Dossier
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EC number: 925-462-9 | CAS number: 1182723-73-4
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
N-Butylamine:
The QSAR determination of the logarithmic octanol-water partition coefficient for N-Butylamine using the model KOWWIN included in the Estimation Program Interface (EPI) Suite v4.11 revealed a value of 0.83 of the substance. The predicted value can be considered reliable yielding a useful result for further assessment.
Bay U 3405 HS:
The experimental determination of the logarithmic octanol-water partition coefficient (log Pow) of BAY U 3405 HS (the corresponding acid of BA-Salz)was 2.8 (at 25 °C).
Key value for chemical safety assessment
Additional information
N-Butylamine:
The logarithmic octanol-water partition coefficient (log Kow) for N-Butylamine was predicted using the QSAR calculation of the Estimation Program Interface (EPI) Suite v 4.11. The log Kow was estimated to be 0.83. The predicted value can be considered reliable yielding a useful result for further assessment.
Bay U 3405 HS:
The logarithmic octanol-water partition coefficient (log Pow) of BAY U 3405 HS (the corresponding acid of BA-Salz) was determined according to EU method A.8 "Determination of partition coefficient", described by EG-guideline 92/69 by reversed phase HPLC. The resulting log Pow was 2.8.
In order to ensure a stable performance of the HPLC column, the column temperature was set to 40 °C. The reference Pow-values in the guideline presumably refer 25 °C. Even though the column temperature was 40 °C, this temperature has no influence on the result of the determination. Therefore, the Pow-value of the test item determined within this study also refers to 25 °C.
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