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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
basic toxicokinetics
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1976 – 2010
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Objective of study:
other: corrosive/ irritation effects... (see attached file)
Qualifier:
no guideline required
Principles of method if other than guideline:
Occupational Medical Assessment
GLP compliance:
no
Species:
human
Sex:
male
Route of administration:
inhalation: dust
Vehicle:
unchanged (no vehicle)
Details on exposure:
dermal exposition
Duration and frequency of treatment / exposure:
n.a.
Remarks:
Doses / Concentrations:
n.a.
No. of animals per sex per dose / concentration:
n.a.
Control animals:
no
Executive summary:

No indication of specific target-organic toxicity could be determined. This also applies for effects on the respiratory tract and the mucous membranes.

Description of key information

No indication of corrosive/irritation effects caused by exposure was shown.
Allergic skin sensitization of the employees with long-term exposure can be practically excluded.
Neither reductions of the pulmonary function appeared nor any indication for an inhalative sensitization due to the inhalation of product dust were given. No indication of a development of malignant neoplasia was observed.
No indication of specific target-organic toxicity could be determined. This also applies for effects on the respiratory tract and the mucous membranes.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information