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Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
chronic toxicity: oral
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Justification for type of information:
The justification document on the read across category approach is included in IUCLID section 13.

Data source

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzenesulfonic acid, 4-C20-24 (even numbered) sec-alkyl derivs.
EC Number:
701-015-1
Cas Number:
2156592-72-0
Molecular formula:
C9H12SO3(CH2)n n=17-21
IUPAC Name:
Benzenesulfonic acid, 4-C20-24 (even numbered) sec-alkyl derivs.
Test material form:
other: liquid
Details on test material:
The test substance is a brown viscous liquid with sulfurous odor.

Results and discussion

Effect levels

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Dose descriptor:
NOAEL
Effect level:
40 mg/kg bw/day (nominal)
Based on:
test mat.
Sex:
male/female
Basis for effect level:
other: increased weight of cecum and slight degeneration of the renal tubes
Dose descriptor:
LOAEL
Effect level:
115 mg/kg bw/day (nominal)
Based on:
test mat.
Sex:
male/female
Basis for effect level:
other: increased weight of cecum and slight degeneration of the renal tubes

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
The test substance is considered to have an NOAEL of 40 mg/kg bw and LOAEL 115 mg/kg bw. The substance is not to be classified as STOT RE according to CLP Regulation.

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