Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-015-1 | CAS number: 2156592-72-0
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No data on acute toxicity to aquatic algae are available for HiMO LABS. Data from a category member LABS Na (CAS no: 68411-30-3) was used to understand the acute and chronic toxicity profile of substance to algae. The 72-hr EbC50 was 47.3 mg/L, and the 72-hr ErC50 was 127.9 mg/L for algae. The 72-hr NOEC for algae was 2.4 mg/L. The 72-hr ErC50 and EbC50 are greater than the water solubility of the target substance. Due to the extremely low water solubility, the acute and chronic toxicity is above the water solubility. As a consequence, HiMo LABS does not demonstrate acute and chronic aquatic toxicity at water soluble concentrations.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 127 mg/L
- EC10 or NOEC for freshwater algae:
- 2.4 mg/L
Additional information
HiMoLABS is an UVCB. Based on the structural and functional similarities, data on LABS Na (CAS no: 68411-30-3) being registered under REACH are considered suitable in case where specific data on the HiMo LABS is lacking.
To assess the acute toxicity profile of the substance to aquatic algae, data was used from LABS Na (CAS no: 68411-30 -3). The acute toxicity to algae of LABS Na was determined in 88/302/EWG guideline study. The 72-hr NOEC for algae was 2.4 mg/L. The 72-hr EbC50 was 47.3 mg/L, and the 72-hr ErC50 was 127.9 mg/L for algae. The 72-hr ErC50 and NOEC are therefore greater than the water solubility of the target substance.
The EPISUITE QSAR modelling was used to predict the acute and chronic toxicity profile of HiMo LABS. Modelled toxicity values for
HiMo LABS (C20 and C24 alkyl derv.) confirmed that the aquatic acute and chronic toxicity value exceeds (i) the predicted water solubility, indicating the substance is not soluble enough to measure the predicted effect and (ii) the log Kow cutoff value of 6.4 and 8.0 for acute and chronic toxicity to green algae, respectively.
According to data from analogue substance and QSAR modelling of HiMo LABS, the substance does not demonstrate acute and
chronic aquatic toxicity at water soluble concentrations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
