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EC number: 701-015-1 | CAS number: 2156592-72-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- The short-term toxicity to aquatic invertebrates can be predicted by read across to the alkyl benzene derivitatives category from which the conclusion can be drawn that an increasing carbon chain length causes a decrease in water solubility. Based on this, it can be expected that the short-term toxicity to aquatic invertebrates for benzene sulfonic acid, C20-24 will be very low. Though as a worst case approach, the result of the category member with the highest water solubility value is used as a boundary value. The read across justification document is attached in IUCLID section 13.
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 2.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality
- Conclusions:
- No chronic fish study with the target substance is available. Data generated with the category substance LABS Na is considered pivotal to this endpoint and this is the most conservative approach. The 48-h LC50 of the target substance can be considered 2.4 mg/L, based on read across to the group alkyl benzene derivatives (worst case approach).
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source
- Justification for type of information:
- QSAR prediction
- Guideline:
- other: REACH guidance on QSARs R.6
- Principles of method if other than guideline:
- Mayo-Bean K., Moran-Bruce K., Nabholz J.V., Meylan W.M., Howard, P.H. 2012. Methodology document for the ecological Structure-Activity Relationship Model (ECOSAR) Class Program
Estimating toxicity of industrial chemcials to aquatic organisms using the ECOSAR class program - Remarks on result:
- other: QSAR result: exceeds (i) the predicted water solubility, indicating the substance is not soluble enough to measure the predicted effect and (ii) the log Kow cutoff value of 5.0 for acute toxicity to daphnia
- Details on results:
- The EPISUITE QSAR modelling was used to predict the acute toxicity profile of HiMo LABS. Modelled toxicity values for HiMo LABS (C20 and C24 alkyl derv.) confirmed that the aquatic acute toxicity value exceeds (i) the predicted water solubility, indicating the substance is not soluble enough to measure the predicted effect and (ii) the log Kow cutoff value of 5.0 for acute toxicity to daphnia.
Based on this, the substance is not expected to demonstrate acute aquatic toxicity at water soluble concentrations. - Conclusions:
- According to data from a substance in the category and QSAR modelling of HiMo LABS, the substance does not demonstrate short-term toxicity to aquatic invertebrates.
Referenceopen allclose all
Description of key information
No data on acute toxicity to aquatic invertebrates is available for HiMO LABS. Structural analogues (alkylbenzene derivatives) were used to understand the acute toxicity profile of substance to daphnia. A study from LABS Na (CAS no: 68411-30-3) was used to cover this endpoint. Using a conservative approach, the 48-hr EC50 was set to 2.4 mg a.i/L. HiMO LABS however has a very low water solubility demonstrated by QSAR modelling. .According to data from a category substance and QSAR modelling of HiMo LABS, indicating an extremely low water solubility, the substance does not demonstrate acute aquatic toxicity to daphnia at water soluble concentrations.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 2.4 mg/L
Additional information
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