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EC number: 701-015-1
CAS number: 2156592-72-0
No data on chronic toxicity to fish is available for the target substance. Data from structural analogues (alkylbenzene derivatives) were used to understand the chronic toxicity profile of the target substance to fish. The most conservative approach indicates a 72-day NOEC for fish of 0.23 mg/L. HiMo LABS however has a very low water solubility demonstrated using QSAR modelling. Furthermore EPISUITE QSAR modelling was used to predict the chronic ecotoxicity profile of HiMo LABS. Modelled toxicity values for HiMo LABS (C20 and C24 alkyl derv.) confirmed that the aquatic chronic toxicity value exceeds the predicted water solubility, leading to the conclusion that it doesn’t exhibit chronic aquatic toxicity. It can be concluded that HiMo LABS (C20 and C24 alkyl derv.) does not demonstrate chronic aquatic toxicity at water soluble concentrations
target substance is an UVCB. Based on structural and functional
similarities, data on LABS Na (CAS no: 68411-30-3) being registered
under REACH, are suitable as supporting in case where specific data on
the target substance are lacking.
is no chronic fish study available on the target substance. A study from LABS
Na (CAS no: 68411-30-3) was used to cover this endpoint.
The lowest NOEC value found was 0.23
mg/L based on survival of eggs exposed from eyed stage, survival of eggs
exposed from fertilization, survival of sac fry, and overall survival
from fertilization to swim-up. This value was greater than the predicted water
solubility of the target substance.
EPISUITE QSAR modelling was used to predict the chronic toxicity profile
of HiMo LABS. Modelled toxicity values for HiMo LABS
and C24 alkyl derv.) confirmed that the aquatic chronic toxicity value
exceeds (i) the predicted water solubility, indicating the substance is
not soluble enough to measure the predicted effect and (ii) the log Kow
cut-off value of 8.0 for chronic toxicity to fish.
to data from a category substance and QSAR modelling of HiMo LABS, the
substance does not demonstrate chronic aquatic
at water soluble concentrations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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