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Physical & Chemical properties

Water solubility

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Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2014
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Principles of method if other than guideline:
None
GLP compliance:
no
Type of method:
flask method
Water solubility:
332 g/L
Temp.:
20 °C
Remarks on result:
other: pH is not known
Details on results:
None

None

Conclusions:
Interpretation of results (migrated information): very soluble (> 10000 mg/L)
The water solubility cs of the test item at a temperature of 20 °C was determined to (without correction for the purity): cs = 332 g/l
Executive summary:

This study was conducted according to OECD guideline 105 .

The water solubility cs of the test item at a temperature of 20 °C was determined to (without correction for the purity): cs = 332 g/l

Endpoint:
water solubility
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH

1. HYPOTHESIS FOR THE ANALOGUE APPROACH
This read-across is based on the hypothesis that the source and the target substance have very similar physicochemical and (eco)toxicological properties because their chemical structures are nearly identical. An analogue approach has thus been employed. The target substance is the meta-isomer of the dye Reactive Blue 049, where the sulphonate group is bound at the meta-position of the aminobenzene moiety. The source chemical is the reaction mass of both the meta-isomer and the para-isomer of Reactive Blue 049.
The presence of sulphonate groups make both dyes highly water soluble and therefore less critical for human health and environmental issues. Based on their chemical similarity, similar properties are expected in both humans and the environment.

2. SOURCE AND TARGET CHEMICAL(S)
Source: Reactive Blue 49 meta/para (CAS# 72214-18-7 / EC# 276-481-8)
Target: Reactive Blue 49 meta (CAS# 72927-99-2 / EC# 277-040-2)

3. ANALOGUE APPROACH JUSTIFICATION
see attachment under 4.2 Melting point / freezing point
Reason / purpose:
read-across source
Key result
Water solubility:
332 g/L
Conc. based on:
test mat.
Temp.:
20 °C
Remarks on result:
other: pH is not reported
Details on results:
None

None

Conclusions:
The water solubility of the test item at a temperature of 20 °C was determined to be 332 g/L
Executive summary:

This study was conducted according to OECD guideline 105 .

The water solubility cs of the test item at a temperature of 20 °C was determined to (without correction for the purity): cs = 332 g/L

Description of key information

The water solubility at a temperature of 20 °C was determined to be 332 g/L

Key value for chemical safety assessment

Water solubility:
332 g/L
at the temperature of:
20 °C

Additional information

This study was conducted according to OECD guideline 105. The water solubility of the source substance at a temperature of 20 °C was determined (without correction for the purity) to be 332 g/L. The structurally related target substance will have a similar very high solubility in water.