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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from publication

Data source

Referenceopen allclose all

Reference Type:
other: authoritative database
Title:
Acute Dermal toxicity - Test chemical
Author:
U.S. National Library of Medicine
Year:
2018
Bibliographic source:
ChemIDplus
Reference Type:
other: Authoritative database
Title:
Toxicity of test chemical
Author:
IFA GESTIS
Year:
2018
Bibliographic source:
GESTIS Substance Database

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute dermal toxicity study of test chemical in rabbits.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1,4-dichlorobenzene
EC Number:
203-400-5
EC Name:
1,4-dichlorobenzene
Cas Number:
106-46-7
Molecular formula:
C6H4Cl2
IUPAC Name:
1,4-dichlorobenzene
Details on test material:
- Name of test material (IUPAC name): 1,4-dichlorobenzene
- Common name: p-Dichlorobenzene
- Molecular formula: C6H4Cl2
- Molecular weight: 147.0036 g/mol
- Smiles notation: c1cc(ccc1Cl)Cl
- InChl: 1S/C6H4Cl2/c7-5-1-2-6(8)4-3-5/h1-4H
- Substance type: Organic

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
not specified
Duration of exposure:
not specified
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
No mortality was observed
Clinical signs:
other: not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
The LD50 value was considered to be >2000 mg/kg bw,when rabbit were treated with test chemical by dermal application.
Executive summary:

In acute dermal toxicity study, rabbit were treated withtest chemicalin the concentration of 2000 mg/kg bw by dermal application.No mortality was observed in treated rabbit at dose 2000 mg/kg bw.Therefore, LD50 value was considered to be >2000 mg/kg bw,when rabbit were treated withtest chemicalby dermal application.