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Ecotoxicological information

Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from computational model developed by USEPA
Justification for type of information:
Data is from computational model developed by USEPA
Qualifier:
according to
Guideline:
other: Modeling database
Principles of method if other than guideline:
ECOSAR v1.00
GLP compliance:
no
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
other: Fish
Test type:
not specified
Water media type:
freshwater
Total exposure duration:
96 h
Hardness:
no data
Test temperature:
no data
pH:
no data
Dissolved oxygen:
no data
Salinity:
no data
Nominal and measured concentrations:
no data
Details on test conditions:
no data
Reference substance (positive control):
not specified
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
1.376 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: ECOSAR Class: Neutral Organic SAR(Baseline Toxicity)
Conclusions:
Based on the QSAR prediction done using the EPI Suite ECOSAR version 1.10, the 96 hours LC50 was estimated to be 1.376 mg/l in freshwater on fish for substance with mortality effects.
Executive summary:

Based on the prediction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to fish was predicted. On the basis of this program, the LC50 value for short term toxicity to aquatic invertebrates was predicted to be 1.376 mg/l for test material in 48 hrs. Based on the above effect concentration value it can be predicted test substance is toxic to fish and can be classified as aquatic acute 2 as per CLP criteria.

Description of key information

Short term toxicity to fish:

Based on the prediction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to fish was predicted. On the basis of this program, the LC50 value for short term toxicity to aquatic invertebrates was predicted to be 1.376 mg/l for test material in 48 hrs. Based on the above effect concentration value it can be predicted test substance is toxic to fish and can be classified as aquatic chronic 2 as per CLP criteria.

Key value for chemical safety assessment

LC50 for freshwater fish:
1.376 mg/L

Additional information

Short term toxicity to fish:

The toxicity of test material was evaluated for fish using a predicted study and to support the prediction , data from secondary source of structurally similar read across substance was also used.

Based on the prediction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to fish was predicted. On the basis of this program, the LC50 value for short term toxicity to aquatic invertebrates was predicted to be 1.376 mg/l for test material in 48 hrs. Based on the above effect concentration value it can be predicted test substance is toxic to fish and can be classified as aquatic chronic 2 as per CLP criteria.

The above prediction was further supported by data from secondary source of structurally similar read across substance, experimental study for test chemical was conducted according to guideline 203. Rainbow Trout (average length, 5.8 cm), were exposed to a series of 5 test concentrations of 0, 7.8, 10.9, 15.3, 21.4, or 30 mg/L dispersed in Polysorbate 80 (10 mg/L) for 96 hours at 17.1 °C. Control fish were exposed to polysorbate 80 (10 mg/L). Fish were observed twice daily for mortality and symptoms. pH values and water temperature were monitored after substance addition at 24 hour intervals. Dissolved oxygen was measured at the beginning of the experiment and at 96 hours. The LC50 value for the given test material is 10.9 mg/L.Based on the above effect concentration it can be concluded that test material is toxic to fish and can be classified as aquatic chronic 2.

According to another study from secondary source for structurally similar read across substance , as per the guideline 203, Rainbow Trout (average length, 6-8 cm), were exposed to a series of 2 test concentrations of 0, 5, or 10 mg/L of test material for 96 hours at 16+/-1°C.During experiment the LC0 was determined to be 5 mg/L while LC100 as 10 mg/L. Thus LC50 value for the given test material was considered to be between 5mg/L and 10 mg/L.Based on the above effect concentration it can be concluded that test material is toxic to fish and can be classified as aquatic chronic 2.

In a data from peer reviewed handbook it was observed that,short term toxicity of test material was evaluated for Leuciscus idus fish for 96 h . The minimum leathel effect concentration (LC50) was observed to be 6.8 mg/l.

Based on the above effect concentrations it can be concluded that test material is toxic to fish and can be classified as aquatic chronic 2.