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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Reference
Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from HSDB and PubChem authoritative database
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Environmental bioconcentration factor of the test chemical in fish was estimated using a logKow and a regression-derived equation.
GLP compliance:
not specified
Radiolabelling:
not specified
Vehicle:
not specified
Test organisms (species):
other: Fish
Route of exposure:
aqueous
Test type:
not specified
Water / sediment media type:
natural water: freshwater
Reference substance (positive control):
not specified
Details on estimation of bioconcentration:
BASIS FOR CALCULATION OF BCF
- Result based on calculated logKow of: 3.85
Type:
BCF
Value:
161 dimensionless
Basis:
whole body w.w.
Calculation basis:
other: BCF value of test chemical was estimated using a logKow and a regression-derived equation.
Remarks on result:
other: Other details not known
Validity criteria fulfilled:
not specified
Conclusions:
The estimated BCF (bioaccumulation factor) of test chemical was determined to be 161 dimensionless.
Executive summary:

The bioaccumulation study in fish was conducted for estimating the BCF (bioaccumulation factor) value of test chemical. The bioaccumulation factor (BCF) value was calculated using a logKow of 3.85 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 161 dimensionless, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is considered to be non-accumulative in aquatic organisms.

Description of key information

The bioaccumulation study in fish was conducted for estimating the BCF (bioaccumulation factor) value of test chemical (authoritative database, 2017). The bioaccumulation factor (BCF) value was calculated using a logKow of 3.85 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 161 dimensionless, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is considered to be non-accumulative in aquatic organisms.

Key value for chemical safety assessment

BCF (aquatic species):
161 dimensionless

Additional information

Various experimental key and supporting studies of the test chemical were reviewed for the bioaccumulation end point which are summarized as below:

 

In an experimental key study from authoritative database (2017), bioaccumulation experiment in fish was conducted for estimating the BCF (bioaccumulation factor) value of test chemical. The bioaccumulation factor (BCF) value was calculated using a logKow of 3.85 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 161 dimensionless.

 

Another bioaccumulation study in fish was conducted for estimating the BCF (bioaccumulation factor) value of test chemical (from handbook, 2008). The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 501 dimensionless.

 

For the test chemical, the bioaccumulation study in fish was conducted for estimating the BCF (bioaccumulation factor) value of test chemical. The bioaccumulation factor (BCF) value was calculated using a measured logKow of 4.0 and an equation (logBCF (fish) = 0.85*logKow – 0.70). The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 501 dimensionless.

 

On the basis of above results for test chemical(from authoritative database and handbook, 2017), it can be concluded that the BCF value of test substancewas evaluated to be upto 501,which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is not expected to bioaccumulate in the food chain.