Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 219-203-2 | CAS number: 2386-57-4
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Data Quality 100%. Data manually curated with highest confidence
Data source
Reference
- Reference Type:
- other:
- Title:
- iCSS CompTox Dashboard, Methanesulfonic acid
- Author:
- U.S. Environmental Protection Agency
- Year:
- 2 016
- Bibliographic source:
- https://comptox.epa.gov/dashboard/DTXSID4026422 (accessed September 01, 2016)
Materials and methods
- Type of study / information:
- High-throughput robotic screening
- Principles of method if other than guideline:
- Using a high-throughput robotic screening system, environmental chemicals and approved drugs (called the Tox21 10K library) were assessed for their potential to disrupt biological pathways that may result in toxicity.
Test material
- Reference substance name:
- Methanesulphonic acid
- EC Number:
- 200-898-6
- EC Name:
- Methanesulphonic acid
- Cas Number:
- 75-75-2
- Molecular formula:
- CH4O3S
- IUPAC Name:
- methanesulfonic acid
Constituent 1
Results and discussion
Any other information on results incl. tables
Methanesulfonic acid
Molecular Formula: CH4O3S
Average Mass: 96.1 g/mol
Monoisotopic Mass: 95.988115 g/mol
Structural Identifiers
IUPAC Name: Methanesulfonic acid
SMILES: CS(O)(=O)=O
InChI String: InChI=1S/CH4O3S/c1-5(2,3)4/h1H3,(H,2,3,4)
InChIKey: AFVFQIVMOAPDHO-UHFFFAOYSA-N
No active results found for Methanesulfonic acid.
Assay Name |
Hit Call |
Top |
Scaled Top |
AC50 |
log AC50 |
Intended Target Family |
TOX21_AR_BLA_Agonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_AR_BLA_Agonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_AR_BLA_Agonist_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
nuclear receptor |
TOX21_AR_BLA_Antagonist_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
nuclear receptor |
TOX21_AR_BLA_Antagonist_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_AR_LUC_MDAKB2_Agonist |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
nuclear receptor |
TOX21_AR_LUC_MDAKB2_Antagonist |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
nuclear receptor |
TOX21_Aromatase_Inhibition |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cyp |
TOX21_AutoFluor_HEK293_Cell_blue |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_AutoFluor_HEK293_Cell_green |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_AutoFluor_HEK293_Cell_red |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_AutoFluor_HEK293_Media_blue |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_AutoFluor_HEK293_Media_green |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_AutoFluor_HEK293_Media_red |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_AutoFluor_HEPG2_Cell_blue |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_AutoFluor_HEPG2_Cell_green |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_AutoFluor_HEPG2_Cell_red |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_AutoFluor_HEPG2_Media_blue |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_AutoFluor_HEPG2_Media_green |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_AutoFluor_HEPG2_Media_red |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_ELG1_LUC_Agonist |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
hydrolase |
TOX21_ERa_BLA_Agonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_ERa_BLA_Agonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_ERa_BLA_Agonist_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
nuclear receptor |
TOX21_ERa_BLA_Antagonist_ratio |
INACTIVE |
7.31 |
0.221 |
0.160 |
-0.795 |
nuclear receptor |
TOX21_ERa_BLA_Antagonist_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_ERa_LUC_BG1_Agonist |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
nuclear receptor |
TOX21_ERa_LUC_BG1_Antagonist |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
nuclear receptor |
TOX21_GR_BLA_Agonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_GR_BLA_Agonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_GR_BLA_Agonist_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
nuclear receptor |
TOX21_GR_BLA_Antagonist_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
nuclear receptor |
TOX21_GR_BLA_Antagonist_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_MMP_ratio_down |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell morphology |
TOX21_MMP_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_PPARg_BLA_Agonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_PPARg_BLA_Agonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_PPARg_BLA_Agonist_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
nuclear receptor |
TOX21_TR_LUC_GH3_Agonist |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
nuclear receptor |
TOX21_TR_LUC_GH3_Antagonist |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
nuclear receptor |
TOX21_AhR_LUC_Agonist |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
dna binding |
TOX21_ARE_BLA_Agonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_ARE_BLA_Agonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_ARE_BLA_agonist_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
dna binding |
TOX21_HSE_BLA_agonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_HSE_BLA_agonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_HSE_BLA_agonist_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
dna binding |
TOX21_p53_BLA_p1_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_p53_BLA_p1_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_p53_BLA_p1_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
dna binding |
TOX21_FXR_BLA_agonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_FXR_BLA_agonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_FXR_BLA_agonist_ratio |
INACTIVE |
5.89 |
0.197 |
0.000855 |
-3.07 |
nuclear receptor |
TOX21_FXR_BLA_antagonist_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
nuclear receptor |
TOX21_FXR_BLA_antagonist_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_PPARd_BLA_agonist_ch1 |
INACTIVE |
822 |
0.292 |
253 |
2.40 |
background measurement |
TOX21_PPARd_BLA_agonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_PPARd_BLA_agonist_ratio |
INACTIVE |
34.0 |
0.495 |
2.80 |
0.448 |
nuclear receptor |
TOX21_PPARd_BLA_antagonist_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
nuclear receptor |
TOX21_PPARd_BLA_antagonist_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_PPARg_BLA_antagonist_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
nuclear receptor |
TOX21_PPARg_BLA_antagonist_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_VDR_BLA_agonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_VDR_BLA_agonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_VDR_BLA_agonist_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cyp |
TOX21_VDR_BLA_antagonist_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cyp |
TOX21_VDR_BLA_antagonist_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_ARE_BLA_agonist_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_HSE_BLA_agonist_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_p53_BLA_p1_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_FXR_BLA_agonist_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_ERa_BLA_Antagonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_ERa_BLA_Antagonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_FXR_BLA_Antagonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_FXR_BLA_Antagonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_GR_BLA_Antagonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_GR_BLA_Antagonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_PPARd_BLA_Agonist_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_PPARd_BLA_Antagonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_PPARd_BLA_Antagonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_PPARg_BLA_Antagonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_PPARg_BLA_Antagonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_VDR_BLA_Antagonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_VDR_BLA_Antagonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_AR_BLA_Antagonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_AR_BLA_Antagonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_p53_BLA_p2_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_p53_BLA_p2_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_p53_BLA_p2_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
dna binding |
TOX21_p53_BLA_p2_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_p53_BLA_p3_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_p53_BLA_p3_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_p53_BLA_p3_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
dna binding |
TOX21_p53_BLA_p3_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_p53_BLA_p4_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_p53_BLA_p4_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_p53_BLA_p4_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
dna binding |
TOX21_p53_BLA_p4_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_p53_BLA_p5_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_p53_BLA_p5_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_p53_BLA_p5_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
dna binding |
TOX21_p53_BLA_p5_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_VDR_BLA_Agonist_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_ESRE_BLA_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_ESRE_BLA_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_ESRE_BLA_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
dna binding |
TOX21_ESRE_BLA_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_NFkB_BLA_agonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_NFkB_BLA_agonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_NFkB_BLA_agonist_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
dna binding |
TOX21_NFkB_BLA_agonist_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_MMP_ratio_up |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell morphology |
TOX21_AR_LUC_MDAKB2_Antagonist2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
- |
Applicant's summary and conclusion
- Conclusions:
- No active results found for Methanesulfonic acid.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
